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Effect of changes in serum calcium on secretin-stimulated serum gastrin in patients with Zollinger-Ellison syndrome.
Gastroenterology. 1982 Jul; 83(1 Pt 2):173-8.G

Abstract

This study was undertaken to determine whether or not the serum gastrin response to secretin in patients with Zollinger-Ellison syndrome is influenced by changes in serum calcium. After infusion of 50 mg/kg disodium ethylenediaminetetraacetate over 90 min in 7 patients with Zollinger-Ellison syndrome, increases in serum gastrin following administration of 1 CU/kg (Cu-clinical unit) secretin GIH (118 +/- 46 pg/ml) were lower than the response before the infusion (755 +/- 90 pg/ml; p less than 0.01). Before infusion of disodium ethylenediaminetetraacetate all 7 patients with Zollinger-Ellison syndrome had gastrin increases after secretin administration above 100 pg/ml, while after the infusion 4 of 7 patients had secretin-stimulated increases in serum gastrin below 100 pg/ml. Subsequent normalization of serum calcium by infusion of 3 mg/kg calcium over 15 min resulted in gastrin responses to secretin of greater than 100 pg/ml. Infusion of 10 mg/kg calcium over 120 min in 4 Zollinger-Ellison syndrome patients induced significant increases in secretin-stimulated serum gastrin from 660 +/- 180 to 1339 +/- 286 pg/ml (p = 0.005). This dose of calcium did not increase the gastrin response to secretin in 5 normogastrinemic and 2 hypergastrinemic control subjects. It was concluded that serum gastrin response to secretin in patient with Zollinger-Ellison syndrome is influenced by serum calcium concentrations.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

6806138

Citation

Jansen, J B., and C B. Lamers. "Effect of Changes in Serum Calcium On Secretin-stimulated Serum Gastrin in Patients With Zollinger-Ellison Syndrome." Gastroenterology, vol. 83, no. 1 Pt 2, 1982, pp. 173-8.
Jansen JB, Lamers CB. Effect of changes in serum calcium on secretin-stimulated serum gastrin in patients with Zollinger-Ellison syndrome. Gastroenterology. 1982;83(1 Pt 2):173-8.
Jansen, J. B., & Lamers, C. B. (1982). Effect of changes in serum calcium on secretin-stimulated serum gastrin in patients with Zollinger-Ellison syndrome. Gastroenterology, 83(1 Pt 2), 173-8.
Jansen JB, Lamers CB. Effect of Changes in Serum Calcium On Secretin-stimulated Serum Gastrin in Patients With Zollinger-Ellison Syndrome. Gastroenterology. 1982;83(1 Pt 2):173-8. PubMed PMID: 6806138.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of changes in serum calcium on secretin-stimulated serum gastrin in patients with Zollinger-Ellison syndrome. AU - Jansen,J B, AU - Lamers,C B, PY - 1982/7/1/pubmed PY - 1982/7/1/medline PY - 1982/7/1/entrez SP - 173 EP - 8 JF - Gastroenterology JO - Gastroenterology VL - 83 IS - 1 Pt 2 N2 - This study was undertaken to determine whether or not the serum gastrin response to secretin in patients with Zollinger-Ellison syndrome is influenced by changes in serum calcium. After infusion of 50 mg/kg disodium ethylenediaminetetraacetate over 90 min in 7 patients with Zollinger-Ellison syndrome, increases in serum gastrin following administration of 1 CU/kg (Cu-clinical unit) secretin GIH (118 +/- 46 pg/ml) were lower than the response before the infusion (755 +/- 90 pg/ml; p less than 0.01). Before infusion of disodium ethylenediaminetetraacetate all 7 patients with Zollinger-Ellison syndrome had gastrin increases after secretin administration above 100 pg/ml, while after the infusion 4 of 7 patients had secretin-stimulated increases in serum gastrin below 100 pg/ml. Subsequent normalization of serum calcium by infusion of 3 mg/kg calcium over 15 min resulted in gastrin responses to secretin of greater than 100 pg/ml. Infusion of 10 mg/kg calcium over 120 min in 4 Zollinger-Ellison syndrome patients induced significant increases in secretin-stimulated serum gastrin from 660 +/- 180 to 1339 +/- 286 pg/ml (p = 0.005). This dose of calcium did not increase the gastrin response to secretin in 5 normogastrinemic and 2 hypergastrinemic control subjects. It was concluded that serum gastrin response to secretin in patient with Zollinger-Ellison syndrome is influenced by serum calcium concentrations. SN - 0016-5085 UR - https://www.unboundmedicine.com/medline/citation/6806138/Effect_of_changes_in_serum_calcium_on_secretin_stimulated_serum_gastrin_in_patients_with_Zollinger_Ellison_syndrome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0016508582001280 DB - PRIME DP - Unbound Medicine ER -