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[Evaluation of dynamic pituitary function testing in patients with hyperprolactinemia on diagnosis of pituitary prolactin-secreting adenoma (author's transl)].
Nihon Sanka Fujinka Gakkai Zasshi. 1982 May; 34(5):569-78.NS

Abstract

Thirty hyperprolactinemic women were divided into four group according to radiological and computed tomographic findings of sella turcica as follows; sulpiride-induced (N = 7), functional (N = 6), microadenoma (N = 9) and macroadenoma (N = 8). It was measured the serum basal level of pituitary LH, FSH, PRL, TSH and GH, and the responsiveness to LH-RH, TRH, insulin administration, respectively. These values were compared to that during bromocriptine treatment (5mg/day, 2 weeks). Before and during treatment with bromocriptine, there were not significant changes of basal level of LH, FSH and TSH, and also the responsiveness to LH-RH administration in four group. In pretreatment period, PRL responsiveness to TRH was good in sulpiride-induced and functional groups, but decreased in microadenoma and macroadenoma groups. During bromocriptine treatment period, basal PRL level was significantly suppressed in three groups except sulpiride-induced group, and PRL responsiveness to TRH was good in three groups except macroadenoma group. These findings ae concluded as follows: 1) Mechanism of the disturbance of ovulation in hyperprolactinemia does not closely related to pituitary gonadotroph dysfunction. 2) Decreased PRL responsiveness to TRH (maximal fold increase: under 40%) is of diagnostic value of pituitary adenomas. 3) Difference of PRL responsiveness to TRH during treatment with bromocriptine is distinguishing the microadenoma from macroadenoma.

Authors

No affiliation info available

Pub Type(s)

Journal Article

Language

jpn

PubMed ID

6806416

Citation

Matsuura, K. "[Evaluation of Dynamic Pituitary Function Testing in Patients With Hyperprolactinemia On Diagnosis of Pituitary Prolactin-secreting Adenoma (author's Transl)]." Nihon Sanka Fujinka Gakkai Zasshi, vol. 34, no. 5, 1982, pp. 569-78.
Matsuura K. [Evaluation of dynamic pituitary function testing in patients with hyperprolactinemia on diagnosis of pituitary prolactin-secreting adenoma (author's transl)]. Nihon Sanka Fujinka Gakkai Zasshi. 1982;34(5):569-78.
Matsuura, K. (1982). [Evaluation of dynamic pituitary function testing in patients with hyperprolactinemia on diagnosis of pituitary prolactin-secreting adenoma (author's transl)]. Nihon Sanka Fujinka Gakkai Zasshi, 34(5), 569-78.
Matsuura K. [Evaluation of Dynamic Pituitary Function Testing in Patients With Hyperprolactinemia On Diagnosis of Pituitary Prolactin-secreting Adenoma (author's Transl)]. Nihon Sanka Fujinka Gakkai Zasshi. 1982;34(5):569-78. PubMed PMID: 6806416.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Evaluation of dynamic pituitary function testing in patients with hyperprolactinemia on diagnosis of pituitary prolactin-secreting adenoma (author's transl)]. A1 - Matsuura,K, PY - 1982/5/1/pubmed PY - 1982/5/1/medline PY - 1982/5/1/entrez SP - 569 EP - 78 JF - Nihon Sanka Fujinka Gakkai zasshi JO - Nihon Sanka Fujinka Gakkai Zasshi VL - 34 IS - 5 N2 - Thirty hyperprolactinemic women were divided into four group according to radiological and computed tomographic findings of sella turcica as follows; sulpiride-induced (N = 7), functional (N = 6), microadenoma (N = 9) and macroadenoma (N = 8). It was measured the serum basal level of pituitary LH, FSH, PRL, TSH and GH, and the responsiveness to LH-RH, TRH, insulin administration, respectively. These values were compared to that during bromocriptine treatment (5mg/day, 2 weeks). Before and during treatment with bromocriptine, there were not significant changes of basal level of LH, FSH and TSH, and also the responsiveness to LH-RH administration in four group. In pretreatment period, PRL responsiveness to TRH was good in sulpiride-induced and functional groups, but decreased in microadenoma and macroadenoma groups. During bromocriptine treatment period, basal PRL level was significantly suppressed in three groups except sulpiride-induced group, and PRL responsiveness to TRH was good in three groups except macroadenoma group. These findings ae concluded as follows: 1) Mechanism of the disturbance of ovulation in hyperprolactinemia does not closely related to pituitary gonadotroph dysfunction. 2) Decreased PRL responsiveness to TRH (maximal fold increase: under 40%) is of diagnostic value of pituitary adenomas. 3) Difference of PRL responsiveness to TRH during treatment with bromocriptine is distinguishing the microadenoma from macroadenoma. SN - 0300-9165 UR - https://www.unboundmedicine.com/medline/citation/6806416/[Evaluation_of_dynamic_pituitary_function_testing_in_patients_with_hyperprolactinemia_on_diagnosis_of_pituitary_prolactin_secreting_adenoma__author's_transl_]_ L2 - http://www.diseaseinfosearch.org/result/2971 DB - PRIME DP - Unbound Medicine ER -