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Bence Jones proteins and light chains of immunoglobulins. Preferential association of the V lambda VI subgroup of human light chains with amyloidosis AL (lambda).
J Clin Invest. 1982 Aug; 70(2):453-60.JCI

Abstract

An antiserum prepared against a lambda-Bence Jones protein from a patient (SUT) who had multiple myeloma and amyloidosis had specificity for lambda-light chains of the chemically defined variable (V) region lambda-chain subgroup lambda VI. Sequence analyses of protein SUT and of five other lambda-light chains recognized immunologically as of the V lambda VI subgroup revealed that all six proteins had the N-terminal sequence characteristic for prototype lambda VI proteins. The isotypic nature of the V lambda VI subgroup was demonstrated immunochemically: lambda VI molecules were detected among light chains isolated from the IgG proteins of each of 12 normal individuals and lambda VI antigenic determinants were also detectable on the intact IgG proteins. The frequency of lambda VI molecules among lambda-type light chains is estimated to be approximately 5% based on the finding that 5 of 91 lambda Bence Jones proteins were of the V lambda VI subgroup. Proteins of the V lambda VI subgroup, in contrast to those of the other five chemically-classified lambda chain subgroup, appear to be preferentially associated with the amyloid process as evidenced by the fact that all six lambda VI proteins were obtained from patients with amyloidosis AL and, in addition, 5 of 42 lambda-type monoclonal immunoglobulins from patients with primary or myeloma-associated amyloidosis were classified by immunodiffusion analyses as having lambda VI-type light chains.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

6808027

Citation

Solomon, A, et al. "Bence Jones Proteins and Light Chains of Immunoglobulins. Preferential Association of the V Lambda VI Subgroup of Human Light Chains With Amyloidosis AL (lambda)." The Journal of Clinical Investigation, vol. 70, no. 2, 1982, pp. 453-60.
Solomon A, Frangione B, Franklin EC. Bence Jones proteins and light chains of immunoglobulins. Preferential association of the V lambda VI subgroup of human light chains with amyloidosis AL (lambda). J Clin Invest. 1982;70(2):453-60.
Solomon, A., Frangione, B., & Franklin, E. C. (1982). Bence Jones proteins and light chains of immunoglobulins. Preferential association of the V lambda VI subgroup of human light chains with amyloidosis AL (lambda). The Journal of Clinical Investigation, 70(2), 453-60.
Solomon A, Frangione B, Franklin EC. Bence Jones Proteins and Light Chains of Immunoglobulins. Preferential Association of the V Lambda VI Subgroup of Human Light Chains With Amyloidosis AL (lambda). J Clin Invest. 1982;70(2):453-60. PubMed PMID: 6808027.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bence Jones proteins and light chains of immunoglobulins. Preferential association of the V lambda VI subgroup of human light chains with amyloidosis AL (lambda). AU - Solomon,A, AU - Frangione,B, AU - Franklin,E C, PY - 1982/8/1/pubmed PY - 1982/8/1/medline PY - 1982/8/1/entrez SP - 453 EP - 60 JF - The Journal of clinical investigation JO - J Clin Invest VL - 70 IS - 2 N2 - An antiserum prepared against a lambda-Bence Jones protein from a patient (SUT) who had multiple myeloma and amyloidosis had specificity for lambda-light chains of the chemically defined variable (V) region lambda-chain subgroup lambda VI. Sequence analyses of protein SUT and of five other lambda-light chains recognized immunologically as of the V lambda VI subgroup revealed that all six proteins had the N-terminal sequence characteristic for prototype lambda VI proteins. The isotypic nature of the V lambda VI subgroup was demonstrated immunochemically: lambda VI molecules were detected among light chains isolated from the IgG proteins of each of 12 normal individuals and lambda VI antigenic determinants were also detectable on the intact IgG proteins. The frequency of lambda VI molecules among lambda-type light chains is estimated to be approximately 5% based on the finding that 5 of 91 lambda Bence Jones proteins were of the V lambda VI subgroup. Proteins of the V lambda VI subgroup, in contrast to those of the other five chemically-classified lambda chain subgroup, appear to be preferentially associated with the amyloid process as evidenced by the fact that all six lambda VI proteins were obtained from patients with amyloidosis AL and, in addition, 5 of 42 lambda-type monoclonal immunoglobulins from patients with primary or myeloma-associated amyloidosis were classified by immunodiffusion analyses as having lambda VI-type light chains. SN - 0021-9738 UR - https://www.unboundmedicine.com/medline/citation/6808027/Bence_Jones_proteins_and_light_chains_of_immunoglobulins__Preferential_association_of_the_V_lambda_VI_subgroup_of_human_light_chains_with_amyloidosis_AL__lambda__ L2 - https://doi.org/10.1172/jci110635 DB - PRIME DP - Unbound Medicine ER -