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Arachidonic acid protection of rat gastric mucosa against ethanol injury.
J Lab Clin Med. 1982 Aug; 100(2):296-308.JL

Abstract

AA, an essential dietary fatty acid, is a precursor for synthesis of prostaglandins. The ability of prostaglandins to protect the gastric mucosa against ethanol injury prompted us to investigate the possibility of AA providing similar protection in the rat. AA or its solubilizer were instilled intragastrically 60 min prior to absolute ethanol. The gastric lining was examined at 3 and 15 hr after the administration of ethanol. The extent of damage was assessed both macroscopically and histologically. AA administration 30 or 60 min prior to ethanol ingestion protected the gastric mucosa against macroscopic and histological damage for 3 to 15 hr. The intragastric concentration of prostaglandin E2 was 5,000 to 13,000 times higher in the animals pretreated with AA than in the controls. The protective action of AA was markedly diminished by indomethacin pretreatment. Intrajejunal administration of AA did not protect the gastric mucosa. These experiments demonstrate that a dietary constitutent--arachidonic acid--can protect the gastric mucosa against alcohol injury by inducing the synthesis of prostaglandins by the gastric mucosa.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

6808067

Citation

Hollander, D, et al. "Arachidonic Acid Protection of Rat Gastric Mucosa Against Ethanol Injury." The Journal of Laboratory and Clinical Medicine, vol. 100, no. 2, 1982, pp. 296-308.
Hollander D, Tarnawski A, Ivey KJ, et al. Arachidonic acid protection of rat gastric mucosa against ethanol injury. J Lab Clin Med. 1982;100(2):296-308.
Hollander, D., Tarnawski, A., Ivey, K. J., DeZeery, A., Zipser, R. D., McKenzie, W. N., & McFarland, W. D. (1982). Arachidonic acid protection of rat gastric mucosa against ethanol injury. The Journal of Laboratory and Clinical Medicine, 100(2), 296-308.
Hollander D, et al. Arachidonic Acid Protection of Rat Gastric Mucosa Against Ethanol Injury. J Lab Clin Med. 1982;100(2):296-308. PubMed PMID: 6808067.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Arachidonic acid protection of rat gastric mucosa against ethanol injury. AU - Hollander,D, AU - Tarnawski,A, AU - Ivey,K J, AU - DeZeery,A, AU - Zipser,R D, AU - McKenzie,W N,Jr AU - McFarland,W D, PY - 1982/8/1/pubmed PY - 2001/3/28/medline PY - 1982/8/1/entrez SP - 296 EP - 308 JF - The Journal of laboratory and clinical medicine JO - J Lab Clin Med VL - 100 IS - 2 N2 - AA, an essential dietary fatty acid, is a precursor for synthesis of prostaglandins. The ability of prostaglandins to protect the gastric mucosa against ethanol injury prompted us to investigate the possibility of AA providing similar protection in the rat. AA or its solubilizer were instilled intragastrically 60 min prior to absolute ethanol. The gastric lining was examined at 3 and 15 hr after the administration of ethanol. The extent of damage was assessed both macroscopically and histologically. AA administration 30 or 60 min prior to ethanol ingestion protected the gastric mucosa against macroscopic and histological damage for 3 to 15 hr. The intragastric concentration of prostaglandin E2 was 5,000 to 13,000 times higher in the animals pretreated with AA than in the controls. The protective action of AA was markedly diminished by indomethacin pretreatment. Intrajejunal administration of AA did not protect the gastric mucosa. These experiments demonstrate that a dietary constitutent--arachidonic acid--can protect the gastric mucosa against alcohol injury by inducing the synthesis of prostaglandins by the gastric mucosa. SN - 0022-2143 UR - https://www.unboundmedicine.com/medline/citation/6808067/Arachidonic_acid_protection_of_rat_gastric_mucosa_against_ethanol_injury_ L2 - https://www.lens.org/lens/search/patent/list?q=citation_id:6808067 DB - PRIME DP - Unbound Medicine ER -