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The oral TRH stimulation test. A new diagnostic tool in "non-toxic" multinodular goitre.
Acta Med Scand. 1982; 211(6):477-80.AM

Abstract

We have developed a 28-hour TRH stimulation test based on the FT3I response to repeated oral TRH stimulation. The normal FT3I response in 15 controls was greater than or equal to 40 arb.U. Twenty-five euthyroid patients with multinodular goitre were studied. Fourteen had normal FT3I responses and normal basal levels of serum T4, FT4I, serum T3 and FT3I. Eleven patients had FT3I responses below 20 arb.U. Although the patients' individual basal values of serum T4, FT4I, serum T3 and FT3I were within the normal range, the median values of FT4I, serum T3 and FT3I were significantly elevated compared to the controls, suggesting that these patients were in a "pretoxic" condition. This assumption seems to be supported by the fact that 3 of these patients subsequently became frankly hyperthyroid, whereas all patients with normal FT3I response remained euthyroid. A comparison between the TSH response to i.v. TRH and the FT3I response to oral TRH showed concordance in 21 of the 25 patients studied.

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Publisher Full Text

Authors

Kirkegaard C
No affiliation info available
Holme Jørgensen P
No affiliation info available
Friis T
No affiliation info available
Siersbaek-Nielsen K
No affiliation info available

MeSH

Administration, OralAdultAgedFemaleGoiter, NodularHumansMaleMiddle AgedPituitary Function TestsThyroid Function TestsThyrotropinThyrotropin-Releasing HormoneThyroxineTriiodothyronine

Pub Type(s)

Journal Article

Language

eng

PubMed ID

6810657

Citation

Kirkegaard, C, et al. "The Oral TRH Stimulation Test. a New Diagnostic Tool in "non-toxic" Multinodular Goitre." Acta Medica Scandinavica, vol. 211, no. 6, 1982, pp. 477-80.
Kirkegaard C, Holme Jørgensen P, Friis T, et al. The oral TRH stimulation test. A new diagnostic tool in "non-toxic" multinodular goitre. Acta Med Scand. 1982;211(6):477-80.
Kirkegaard, C., Holme Jørgensen, P., Friis, T., & Siersbaek-Nielsen, K. (1982). The oral TRH stimulation test. A new diagnostic tool in "non-toxic" multinodular goitre. Acta Medica Scandinavica, 211(6), 477-80.
Kirkegaard C, et al. The Oral TRH Stimulation Test. a New Diagnostic Tool in "non-toxic" Multinodular Goitre. Acta Med Scand. 1982;211(6):477-80. PubMed PMID: 6810657.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The oral TRH stimulation test. A new diagnostic tool in "non-toxic" multinodular goitre. AU - Kirkegaard,C, AU - Holme Jørgensen,P, AU - Friis,T, AU - Siersbaek-Nielsen,K, PY - 1982/1/1/pubmed PY - 1982/1/1/medline PY - 1982/1/1/entrez SP - 477 EP - 80 JF - Acta medica Scandinavica JO - Acta Med Scand VL - 211 IS - 6 N2 - We have developed a 28-hour TRH stimulation test based on the FT3I response to repeated oral TRH stimulation. The normal FT3I response in 15 controls was greater than or equal to 40 arb.U. Twenty-five euthyroid patients with multinodular goitre were studied. Fourteen had normal FT3I responses and normal basal levels of serum T4, FT4I, serum T3 and FT3I. Eleven patients had FT3I responses below 20 arb.U. Although the patients' individual basal values of serum T4, FT4I, serum T3 and FT3I were within the normal range, the median values of FT4I, serum T3 and FT3I were significantly elevated compared to the controls, suggesting that these patients were in a "pretoxic" condition. This assumption seems to be supported by the fact that 3 of these patients subsequently became frankly hyperthyroid, whereas all patients with normal FT3I response remained euthyroid. A comparison between the TSH response to i.v. TRH and the FT3I response to oral TRH showed concordance in 21 of the 25 patients studied. SN - 0001-6101 UR - https://www.unboundmedicine.com/medline/citation/6810657/The_oral_TRH_stimulation_test__A_new_diagnostic_tool_in_"non_toxic"_multinodular_goitre_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0001-6101&date=1982&volume=211&issue=6&spage=477 DB - PRIME DP - Unbound Medicine ER -