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Treatment of tinnitus with tocainide hydrochloride.
Otolaryngol Head Neck Surg. 1980 Jul-Aug; 88(4):442-6.OH

Abstract

Intravenous (IV) injection of lidocaine was used in patients with tinnitus for combined treatment with oral anticonvulsants carbamazepine (Tegretol) and primidone (Mysoline). In most cases, the high complication rate with these drugs precluded their long-term use. Tocainide hydrochloride (HCl), a primary amine analog of lidocaine, can be taken orally and was evaluated for the use in the treatment of tinnitus. A double-blind study in which one group received 200 mg tocainide HCl four times a day and one group received a placebo revealed no significant differences in tinnitus relief between the two groups. A single-blind study in which 600 mg tocainide HCl four times a day was administered showed 80% to 98% tinnitus relief in five of the six patients who tolerated the drug. Tocainide HCl treatment of tinnitus is promising.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

6821429

Citation

Emmett, J R., and J J. Shea. "Treatment of Tinnitus With Tocainide Hydrochloride." Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery, vol. 88, no. 4, 1980, pp. 442-6.
Emmett JR, Shea JJ. Treatment of tinnitus with tocainide hydrochloride. Otolaryngol Head Neck Surg. 1980;88(4):442-6.
Emmett, J. R., & Shea, J. J. (1980). Treatment of tinnitus with tocainide hydrochloride. Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery, 88(4), 442-6.
Emmett JR, Shea JJ. Treatment of Tinnitus With Tocainide Hydrochloride. Otolaryngol Head Neck Surg. 1980 Jul-Aug;88(4):442-6. PubMed PMID: 6821429.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Treatment of tinnitus with tocainide hydrochloride. AU - Emmett,J R, AU - Shea,J J, PY - 1980/7/1/pubmed PY - 1980/7/1/medline PY - 1980/7/1/entrez SP - 442 EP - 6 JF - Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery JO - Otolaryngol Head Neck Surg VL - 88 IS - 4 N2 - Intravenous (IV) injection of lidocaine was used in patients with tinnitus for combined treatment with oral anticonvulsants carbamazepine (Tegretol) and primidone (Mysoline). In most cases, the high complication rate with these drugs precluded their long-term use. Tocainide hydrochloride (HCl), a primary amine analog of lidocaine, can be taken orally and was evaluated for the use in the treatment of tinnitus. A double-blind study in which one group received 200 mg tocainide HCl four times a day and one group received a placebo revealed no significant differences in tinnitus relief between the two groups. A single-blind study in which 600 mg tocainide HCl four times a day was administered showed 80% to 98% tinnitus relief in five of the six patients who tolerated the drug. Tocainide HCl treatment of tinnitus is promising. SN - 0194-5998 UR - https://www.unboundmedicine.com/medline/citation/6821429/Treatment_of_tinnitus_with_tocainide_hydrochloride_ L2 - http://www.diseaseinfosearch.org/result/9653 DB - PRIME DP - Unbound Medicine ER -