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Placebo controlled double blind study with pentoxifylline of walking performance in patients with intermittent claudication.
Angiology. 1983 Jan; 34(1):40-5.A

Abstract

A double blind placebo-controlled randomised crossover study was performed with Pentoxifylline (Trental 400 tablets with 400 mg active ingredient) in 24 patients (19 males, 5 females, aged between 40 and 71 years) suffering from peripheral occlusive arteriopathy of stage II severity (Fontaine's classification). In 12 patients (group I) the treatment was started with placebo, and in another 12 subjects with Pentoxifylline (group II). The dosage was 3 tablets of either formulation t.d.s., the treatment periods were 8 weeks each with a two week washout between. The standardised walking test (120 steps/min under metronome control) was used for the assessment of the walking capacity. There was a significant 60% increase in pain-free walking distance in either Pentoxifylline treatment periods, whereas there were no clinically relevant changes in the placebo periods. When comparing the two starting periods only, there was an increase in the Pentoxifylline group from 223 to 359 m on average and in the placebo group from 208 to 215 m, patients in both groups being comparable at basal level as to the distribution of sex, age, location of occlusion, duration of disease as well as in respect to the walking capacity. No adverse reactions were recorded during the trial.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

6824189

Citation

Di Perri, T, and M Guerrini. "Placebo Controlled Double Blind Study With Pentoxifylline of Walking Performance in Patients With Intermittent Claudication." Angiology, vol. 34, no. 1, 1983, pp. 40-5.
Di Perri T, Guerrini M. Placebo controlled double blind study with pentoxifylline of walking performance in patients with intermittent claudication. Angiology. 1983;34(1):40-5.
Di Perri, T., & Guerrini, M. (1983). Placebo controlled double blind study with pentoxifylline of walking performance in patients with intermittent claudication. Angiology, 34(1), 40-5.
Di Perri T, Guerrini M. Placebo Controlled Double Blind Study With Pentoxifylline of Walking Performance in Patients With Intermittent Claudication. Angiology. 1983;34(1):40-5. PubMed PMID: 6824189.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Placebo controlled double blind study with pentoxifylline of walking performance in patients with intermittent claudication. AU - Di Perri,T, AU - Guerrini,M, PY - 1983/1/1/pubmed PY - 1983/1/1/medline PY - 1983/1/1/entrez SP - 40 EP - 5 JF - Angiology JO - Angiology VL - 34 IS - 1 N2 - A double blind placebo-controlled randomised crossover study was performed with Pentoxifylline (Trental 400 tablets with 400 mg active ingredient) in 24 patients (19 males, 5 females, aged between 40 and 71 years) suffering from peripheral occlusive arteriopathy of stage II severity (Fontaine's classification). In 12 patients (group I) the treatment was started with placebo, and in another 12 subjects with Pentoxifylline (group II). The dosage was 3 tablets of either formulation t.d.s., the treatment periods were 8 weeks each with a two week washout between. The standardised walking test (120 steps/min under metronome control) was used for the assessment of the walking capacity. There was a significant 60% increase in pain-free walking distance in either Pentoxifylline treatment periods, whereas there were no clinically relevant changes in the placebo periods. When comparing the two starting periods only, there was an increase in the Pentoxifylline group from 223 to 359 m on average and in the placebo group from 208 to 215 m, patients in both groups being comparable at basal level as to the distribution of sex, age, location of occlusion, duration of disease as well as in respect to the walking capacity. No adverse reactions were recorded during the trial. SN - 0003-3197 UR - https://www.unboundmedicine.com/medline/citation/6824189/Placebo_controlled_double_blind_study_with_pentoxifylline_of_walking_performance_in_patients_with_intermittent_claudication_ L2 - http://journals.sagepub.com/doi/full/10.1177/000331978303400105?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -