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Superoxide dismutase, catalase and glutathione peroxidase in the human cataractous lens.
Exp Eye Res. 1983 Jan; 36(1):15-23.EE

Abstract

The activities of the protective enzymes, superoxide dismutase, catalase and glutathione peroxidase have been measured in the cortical and nuclear sections of 76 human cataractous lenses as well as in calf, rabbit and rat lenses. No changes was observed in the activity of catalase with the progressive development of cataract. However, a precipitous decrease (70%) in both superoxide dismutase and glutathione peroxidase in the nuclear region of the lens was found at the onset of nuclear cataract. Further decreases accompanied the progression of the cataract and similar, but less marked, decreases were observed in the cortical region of the lens. It is suggested that the inactivation of these enzymes may result in an elevation of the H2O2 and O2.- levels in the lens and that this may be responsible for the oxidative modification of lens proteins observed in nuclear cataracts.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

6825728

Citation

Fecondo, J V., and R C. Augusteyn. "Superoxide Dismutase, Catalase and Glutathione Peroxidase in the Human Cataractous Lens." Experimental Eye Research, vol. 36, no. 1, 1983, pp. 15-23.
Fecondo JV, Augusteyn RC. Superoxide dismutase, catalase and glutathione peroxidase in the human cataractous lens. Exp Eye Res. 1983;36(1):15-23.
Fecondo, J. V., & Augusteyn, R. C. (1983). Superoxide dismutase, catalase and glutathione peroxidase in the human cataractous lens. Experimental Eye Research, 36(1), 15-23.
Fecondo JV, Augusteyn RC. Superoxide Dismutase, Catalase and Glutathione Peroxidase in the Human Cataractous Lens. Exp Eye Res. 1983;36(1):15-23. PubMed PMID: 6825728.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Superoxide dismutase, catalase and glutathione peroxidase in the human cataractous lens. AU - Fecondo,J V, AU - Augusteyn,R C, PY - 1983/1/1/pubmed PY - 1983/1/1/medline PY - 1983/1/1/entrez SP - 15 EP - 23 JF - Experimental eye research JO - Exp Eye Res VL - 36 IS - 1 N2 - The activities of the protective enzymes, superoxide dismutase, catalase and glutathione peroxidase have been measured in the cortical and nuclear sections of 76 human cataractous lenses as well as in calf, rabbit and rat lenses. No changes was observed in the activity of catalase with the progressive development of cataract. However, a precipitous decrease (70%) in both superoxide dismutase and glutathione peroxidase in the nuclear region of the lens was found at the onset of nuclear cataract. Further decreases accompanied the progression of the cataract and similar, but less marked, decreases were observed in the cortical region of the lens. It is suggested that the inactivation of these enzymes may result in an elevation of the H2O2 and O2.- levels in the lens and that this may be responsible for the oxidative modification of lens proteins observed in nuclear cataracts. SN - 0014-4835 UR - https://www.unboundmedicine.com/medline/citation/6825728/Superoxide_dismutase_catalase_and_glutathione_peroxidase_in_the_human_cataractous_lens_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0014-4835(83)90085-4 DB - PRIME DP - Unbound Medicine ER -