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Vasoactive intestinal peptide and cholinergic neurotransmission in the ciliary muscle.
Invest Ophthalmol Vis Sci. 1983 Feb; 24(2):250-3.IO

Abstract

The effects of vasoactive intestinal peptide (VIP) on mechanical activity and electrical stimulation of the bovine ciliary muscle in vitro were compared. The generated contractions were enhanced by application of eserine and were abolished completely in the presence of atropine. VIP (10(-8)-10(-6) M) enhanced the response to electrical stimulation, while the contractile amplitude of the ciliary muscle to exogenous carbachol was not altered significantly by application of 10(-7)-10(-6) M VIP. The exogenous VIP had no direct effect on the muscle. As these data indicate that VIP exerts its stimulant effect, prejunctionally, ie, on the nerve terminals, this peptide probably contributes to the control of accommodation as a modulator of cholinergic neurotransmission between short ciliary nerves and the ciliary muscle.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

6826329

Citation

Suzuki, R, and S Kobayashi. "Vasoactive Intestinal Peptide and Cholinergic Neurotransmission in the Ciliary Muscle." Investigative Ophthalmology & Visual Science, vol. 24, no. 2, 1983, pp. 250-3.
Suzuki R, Kobayashi S. Vasoactive intestinal peptide and cholinergic neurotransmission in the ciliary muscle. Invest Ophthalmol Vis Sci. 1983;24(2):250-3.
Suzuki, R., & Kobayashi, S. (1983). Vasoactive intestinal peptide and cholinergic neurotransmission in the ciliary muscle. Investigative Ophthalmology & Visual Science, 24(2), 250-3.
Suzuki R, Kobayashi S. Vasoactive Intestinal Peptide and Cholinergic Neurotransmission in the Ciliary Muscle. Invest Ophthalmol Vis Sci. 1983;24(2):250-3. PubMed PMID: 6826329.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vasoactive intestinal peptide and cholinergic neurotransmission in the ciliary muscle. AU - Suzuki,R, AU - Kobayashi,S, PY - 1983/2/1/pubmed PY - 1983/2/1/medline PY - 1983/2/1/entrez SP - 250 EP - 3 JF - Investigative ophthalmology & visual science JO - Invest. Ophthalmol. Vis. Sci. VL - 24 IS - 2 N2 - The effects of vasoactive intestinal peptide (VIP) on mechanical activity and electrical stimulation of the bovine ciliary muscle in vitro were compared. The generated contractions were enhanced by application of eserine and were abolished completely in the presence of atropine. VIP (10(-8)-10(-6) M) enhanced the response to electrical stimulation, while the contractile amplitude of the ciliary muscle to exogenous carbachol was not altered significantly by application of 10(-7)-10(-6) M VIP. The exogenous VIP had no direct effect on the muscle. As these data indicate that VIP exerts its stimulant effect, prejunctionally, ie, on the nerve terminals, this peptide probably contributes to the control of accommodation as a modulator of cholinergic neurotransmission between short ciliary nerves and the ciliary muscle. SN - 0146-0404 UR - https://www.unboundmedicine.com/medline/citation/6826329/Vasoactive_intestinal_peptide_and_cholinergic_neurotransmission_in_the_ciliary_muscle_ L2 - https://iovs.arvojournals.org/article.aspx?volume=24&issue=2&page=250 DB - PRIME DP - Unbound Medicine ER -