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Differences between d-fenfluramine and d-norfenfluramine in serotonin presynaptic mechanisms.
J Neurochem. 1983 Mar; 40(3):891-3.JN

Abstract

The abilities of d-fenfluramine (d-F) and that of d-norfenfluramine (d-NF) to inhibit [3H]serotonin ([3H]5-HT) accumulation in normal and reserpinized synaptosomes were compared to establish to what extent the serotonin-releasing activity of the two drugs might contribute to reduced accumulation of [3H]5-HT. The results indicate that the inhibitory action of (d-NF) on [3H]5-HT accumulation is due principally to its ability to release [3H]5-HT. In contrast, the interference of release in accumulation studies does not seem to play an important role for d-F, suggesting that release from the granular pool and true uptake inhibition are two different mechanisms by which d-F affects serotonin neurons in vitro.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

6827286

Citation

Borroni, E, et al. "Differences Between D-fenfluramine and D-norfenfluramine in Serotonin Presynaptic Mechanisms." Journal of Neurochemistry, vol. 40, no. 3, 1983, pp. 891-3.
Borroni E, Ceci A, Garattini S, et al. Differences between d-fenfluramine and d-norfenfluramine in serotonin presynaptic mechanisms. J Neurochem. 1983;40(3):891-3.
Borroni, E., Ceci, A., Garattini, S., & Mennini, T. (1983). Differences between d-fenfluramine and d-norfenfluramine in serotonin presynaptic mechanisms. Journal of Neurochemistry, 40(3), 891-3.
Borroni E, et al. Differences Between D-fenfluramine and D-norfenfluramine in Serotonin Presynaptic Mechanisms. J Neurochem. 1983;40(3):891-3. PubMed PMID: 6827286.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differences between d-fenfluramine and d-norfenfluramine in serotonin presynaptic mechanisms. AU - Borroni,E, AU - Ceci,A, AU - Garattini,S, AU - Mennini,T, PY - 1983/3/1/pubmed PY - 1983/3/1/medline PY - 1983/3/1/entrez SP - 891 EP - 3 JF - Journal of neurochemistry JO - J Neurochem VL - 40 IS - 3 N2 - The abilities of d-fenfluramine (d-F) and that of d-norfenfluramine (d-NF) to inhibit [3H]serotonin ([3H]5-HT) accumulation in normal and reserpinized synaptosomes were compared to establish to what extent the serotonin-releasing activity of the two drugs might contribute to reduced accumulation of [3H]5-HT. The results indicate that the inhibitory action of (d-NF) on [3H]5-HT accumulation is due principally to its ability to release [3H]5-HT. In contrast, the interference of release in accumulation studies does not seem to play an important role for d-F, suggesting that release from the granular pool and true uptake inhibition are two different mechanisms by which d-F affects serotonin neurons in vitro. SN - 0022-3042 UR - https://www.unboundmedicine.com/medline/citation/6827286/Differences_between_d_fenfluramine_and_d_norfenfluramine_in_serotonin_presynaptic_mechanisms_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0022-3042&date=1983&volume=40&issue=3&spage=891 DB - PRIME DP - Unbound Medicine ER -