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Growth and development in children with sickle-cell trait. A prospective study of matched pairs.
N Engl J Med. 1978 Sep 28; 299(13):686-9.NEJM

Abstract

To ascertain if sickle-cell trait (Hb AS) impairs physical growth and cognitive development, we prospectively investigated 50 matched pairs of black children. For each child with Hb AS, an Hb AA child was matched at birth for sex, birth date, birth weight, gestational age, five-minute Apgar score and socioeconomic status. Between the ages of three and five years, the members of each matched pair were evaluated, with one month of one another, by persons "blind" to the hemoglobin genotype. Twelve outcome measurements were obtained at evaluation: height, weight, head circumference, skin-fold thickness, cross-sectional area of arm muscle, bone age, five scores of the McCarthy Scales of Children's Abilities, and the Peabody Picture Vocabulary Test. There were no statistically significant differences in these measurements favoring the AA group. The results show that children with sickle-cell trait in this age group have no deficits in standard measurements of growth and development and emphasize the importance of rigorous methods when clinical groups are assembled and compared.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

683252

Citation

Kramer, M S., et al. "Growth and Development in Children With Sickle-cell Trait. a Prospective Study of Matched Pairs." The New England Journal of Medicine, vol. 299, no. 13, 1978, pp. 686-9.
Kramer MS, Rooks Y, Pearson HA. Growth and development in children with sickle-cell trait. A prospective study of matched pairs. N Engl J Med. 1978;299(13):686-9.
Kramer, M. S., Rooks, Y., & Pearson, H. A. (1978). Growth and development in children with sickle-cell trait. A prospective study of matched pairs. The New England Journal of Medicine, 299(13), 686-9.
Kramer MS, Rooks Y, Pearson HA. Growth and Development in Children With Sickle-cell Trait. a Prospective Study of Matched Pairs. N Engl J Med. 1978 Sep 28;299(13):686-9. PubMed PMID: 683252.
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TY - JOUR T1 - Growth and development in children with sickle-cell trait. A prospective study of matched pairs. AU - Kramer,M S, AU - Rooks,Y, AU - Pearson,H A, PY - 1978/9/28/pubmed PY - 1978/9/28/medline PY - 1978/9/28/entrez SP - 686 EP - 9 JF - The New England journal of medicine JO - N Engl J Med VL - 299 IS - 13 N2 - To ascertain if sickle-cell trait (Hb AS) impairs physical growth and cognitive development, we prospectively investigated 50 matched pairs of black children. For each child with Hb AS, an Hb AA child was matched at birth for sex, birth date, birth weight, gestational age, five-minute Apgar score and socioeconomic status. Between the ages of three and five years, the members of each matched pair were evaluated, with one month of one another, by persons "blind" to the hemoglobin genotype. Twelve outcome measurements were obtained at evaluation: height, weight, head circumference, skin-fold thickness, cross-sectional area of arm muscle, bone age, five scores of the McCarthy Scales of Children's Abilities, and the Peabody Picture Vocabulary Test. There were no statistically significant differences in these measurements favoring the AA group. The results show that children with sickle-cell trait in this age group have no deficits in standard measurements of growth and development and emphasize the importance of rigorous methods when clinical groups are assembled and compared. SN - 0028-4793 UR - https://www.unboundmedicine.com/medline/citation/683252/Growth_and_development_in_children_with_sickle_cell_trait__A_prospective_study_of_matched_pairs_ L2 - https://www.nejm.org/doi/10.1056/NEJM197809282991303?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -