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Free erythrocyte protoporphyrin (FEP) I. Normal values for adults and evaluation of the hematofluorometer.
Am J Clin Pathol. 1983 Jun; 79(6):655-60.AJ

Abstract

Since the early 1970s, measurement of free erythrocyte protoporphyrin (FEP) (by microextraction or by hematofluorometer) has been widely used to screen for lead poisoning and to evaluate microcytic red blood cell (RBC) disorders in children. However, published information on normal values for FEP, performance of the hematofluorometer, and usefulness of FEP in classifying microcytic RBC disorders in adults is scant. In an adult population with normal hematocrit and MCV and normal values for serum ferritin, blood lead level, and serum bilirubin, we obtained normal hematofluorometer FEP levels of less than 30 micrograms/dL for men, and less than 40 micrograms/dL levels for women. We have evaluated a hematofluorometer against a standard microextraction procedure and feel that the hematofluorometer is superior for clinical laboratories if elevated FEPs are confirmed by retesting with washed RBC. In the second part of this paper we demonstrate the usefulness of the FEP in classifying microcytic RBC disorders in adults.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

6846255

Citation

Marsh, W L., et al. "Free Erythrocyte Protoporphyrin (FEP) I. Normal Values for Adults and Evaluation of the Hematofluorometer." American Journal of Clinical Pathology, vol. 79, no. 6, 1983, pp. 655-60.
Marsh WL, Nelson DP, Koenig HM. Free erythrocyte protoporphyrin (FEP) I. Normal values for adults and evaluation of the hematofluorometer. Am J Clin Pathol. 1983;79(6):655-60.
Marsh, W. L., Nelson, D. P., & Koenig, H. M. (1983). Free erythrocyte protoporphyrin (FEP) I. Normal values for adults and evaluation of the hematofluorometer. American Journal of Clinical Pathology, 79(6), 655-60.
Marsh WL, Nelson DP, Koenig HM. Free Erythrocyte Protoporphyrin (FEP) I. Normal Values for Adults and Evaluation of the Hematofluorometer. Am J Clin Pathol. 1983;79(6):655-60. PubMed PMID: 6846255.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Free erythrocyte protoporphyrin (FEP) I. Normal values for adults and evaluation of the hematofluorometer. AU - Marsh,W L,Jr AU - Nelson,D P, AU - Koenig,H M, PY - 1983/6/1/pubmed PY - 2001/3/28/medline PY - 1983/6/1/entrez SP - 655 EP - 60 JF - American journal of clinical pathology JO - Am J Clin Pathol VL - 79 IS - 6 N2 - Since the early 1970s, measurement of free erythrocyte protoporphyrin (FEP) (by microextraction or by hematofluorometer) has been widely used to screen for lead poisoning and to evaluate microcytic red blood cell (RBC) disorders in children. However, published information on normal values for FEP, performance of the hematofluorometer, and usefulness of FEP in classifying microcytic RBC disorders in adults is scant. In an adult population with normal hematocrit and MCV and normal values for serum ferritin, blood lead level, and serum bilirubin, we obtained normal hematofluorometer FEP levels of less than 30 micrograms/dL for men, and less than 40 micrograms/dL levels for women. We have evaluated a hematofluorometer against a standard microextraction procedure and feel that the hematofluorometer is superior for clinical laboratories if elevated FEPs are confirmed by retesting with washed RBC. In the second part of this paper we demonstrate the usefulness of the FEP in classifying microcytic RBC disorders in adults. SN - 0002-9173 UR - https://www.unboundmedicine.com/medline/citation/6846255/Free_erythrocyte_protoporphyrin__FEP__I__Normal_values_for_adults_and_evaluation_of_the_hematofluorometer_ L2 - https://academic.oup.com/ajcp/article-lookup/doi/10.1093/ajcp/79.6.655 DB - PRIME DP - Unbound Medicine ER -