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Necrobiotic xanthogranuloma of the eyelid.
Arch Ophthalmol. 1983 Jan; 101(1):60-3.AO

Abstract

Necrobiotic xanthogranuloma with paraproteinemia is characterized by multiple nodules or plaques that involve the periorbital area along with other parts of the body. A dysproteinemia due to an IgG paraprotein is associated with the condition; low serum complement, cryoglobulinemia, leukopenia, and hyperlipemia are also sometimes seen. Multiple myeloma is present in some cases. Two cases of necrobiotic xanthogranuloma with IgG monoclonal gammopathy were seen. Both initially had ocular symptoms and in the second case, the ocular manifestations have dominated the clinical picture. Histologically, these granulomas are characterized by collagen necrobiosis and by the presence of many foamy histiocytes and Touton giant cells. Because necrobiotic xanthogranuloma with monoclonal gammopathy frequently has prominent manifestations in the orbital region, may result in dysfunction of the eyelids or extraocular muscles, and is associated with potentially life-threatening systemic conditions, its recognition by the ophthalmologist is important.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

6849654

Citation

Codère, F, et al. "Necrobiotic Xanthogranuloma of the Eyelid." Archives of Ophthalmology (Chicago, Ill. : 1960), vol. 101, no. 1, 1983, pp. 60-3.
Codère F, Lee RD, Anderson RL. Necrobiotic xanthogranuloma of the eyelid. Arch Ophthalmol. 1983;101(1):60-3.
Codère, F., Lee, R. D., & Anderson, R. L. (1983). Necrobiotic xanthogranuloma of the eyelid. Archives of Ophthalmology (Chicago, Ill. : 1960), 101(1), 60-3.
Codère F, Lee RD, Anderson RL. Necrobiotic Xanthogranuloma of the Eyelid. Arch Ophthalmol. 1983;101(1):60-3. PubMed PMID: 6849654.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Necrobiotic xanthogranuloma of the eyelid. AU - Codère,F, AU - Lee,R D, AU - Anderson,R L, PY - 1983/1/1/pubmed PY - 1983/1/1/medline PY - 1983/1/1/entrez SP - 60 EP - 3 JF - Archives of ophthalmology (Chicago, Ill. : 1960) JO - Arch. Ophthalmol. VL - 101 IS - 1 N2 - Necrobiotic xanthogranuloma with paraproteinemia is characterized by multiple nodules or plaques that involve the periorbital area along with other parts of the body. A dysproteinemia due to an IgG paraprotein is associated with the condition; low serum complement, cryoglobulinemia, leukopenia, and hyperlipemia are also sometimes seen. Multiple myeloma is present in some cases. Two cases of necrobiotic xanthogranuloma with IgG monoclonal gammopathy were seen. Both initially had ocular symptoms and in the second case, the ocular manifestations have dominated the clinical picture. Histologically, these granulomas are characterized by collagen necrobiosis and by the presence of many foamy histiocytes and Touton giant cells. Because necrobiotic xanthogranuloma with monoclonal gammopathy frequently has prominent manifestations in the orbital region, may result in dysfunction of the eyelids or extraocular muscles, and is associated with potentially life-threatening systemic conditions, its recognition by the ophthalmologist is important. SN - 0003-9950 UR - https://www.unboundmedicine.com/medline/citation/6849654/Necrobiotic_xanthogranuloma_of_the_eyelid_ L2 - https://jamanetwork.com/journals/jamaophthalmology/fullarticle/vol/101/pg/60 DB - PRIME DP - Unbound Medicine ER -