Tags

Type your tag names separated by a space and hit enter

[The sterile Behçet pustule: a typical skin manifestation of the Behçet syndrome].
Dtsch Med Wochenschr. 1983 May 27; 108(21):820-5.DM

Abstract

Solitary pustules were excised from five patients with Behçet's syndrome and examined histologically, immunohistologically, and--in one case--by immunoelectron microscopy. Histologically the changes were largely confined to the venules of the middle and lower corium. The endothelium was swollen, in part the vascular walls were destroyed. In the perivascular spaces there was round-cell infiltration, mixed with numerous neutrophilic granulocytes, some of them disintegrated. Immunofluorescence-microscopy revealed perivascular deposition of complement C3 and C1q. In fresh lesions there were also IgG or IgM precipitates. Immuno-electron microscopy also demonstrated complement C3 subendothelially. Fibrin deposition and disintegrating neutrophilic granulocytes marked the leukocytoclastic vasculitis. Taken together the findings indicate that an immune-complex vasculitis takes part in the pathogenic mechanism of pustule formation in Behcet's syndrome.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

ger

PubMed ID

6851872

Citation

Braun-Falco, O, et al. "[The Sterile Behçet Pustule: a Typical Skin Manifestation of the Behçet Syndrome]." Deutsche Medizinische Wochenschrift (1946), vol. 108, no. 21, 1983, pp. 820-5.
Braun-Falco O, Luderschmidt C, Wolff HH. [The sterile Behçet pustule: a typical skin manifestation of the Behçet syndrome]. Dtsch Med Wochenschr. 1983;108(21):820-5.
Braun-Falco, O., Luderschmidt, C., & Wolff, H. H. (1983). [The sterile Behçet pustule: a typical skin manifestation of the Behçet syndrome]. Deutsche Medizinische Wochenschrift (1946), 108(21), 820-5.
Braun-Falco O, Luderschmidt C, Wolff HH. [The Sterile Behçet Pustule: a Typical Skin Manifestation of the Behçet Syndrome]. Dtsch Med Wochenschr. 1983 May 27;108(21):820-5. PubMed PMID: 6851872.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The sterile Behçet pustule: a typical skin manifestation of the Behçet syndrome]. AU - Braun-Falco,O, AU - Luderschmidt,C, AU - Wolff,H H, PY - 1983/5/27/pubmed PY - 1983/5/27/medline PY - 1983/5/27/entrez SP - 820 EP - 5 JF - Deutsche medizinische Wochenschrift (1946) JO - Dtsch. Med. Wochenschr. VL - 108 IS - 21 N2 - Solitary pustules were excised from five patients with Behçet's syndrome and examined histologically, immunohistologically, and--in one case--by immunoelectron microscopy. Histologically the changes were largely confined to the venules of the middle and lower corium. The endothelium was swollen, in part the vascular walls were destroyed. In the perivascular spaces there was round-cell infiltration, mixed with numerous neutrophilic granulocytes, some of them disintegrated. Immunofluorescence-microscopy revealed perivascular deposition of complement C3 and C1q. In fresh lesions there were also IgG or IgM precipitates. Immuno-electron microscopy also demonstrated complement C3 subendothelially. Fibrin deposition and disintegrating neutrophilic granulocytes marked the leukocytoclastic vasculitis. Taken together the findings indicate that an immune-complex vasculitis takes part in the pathogenic mechanism of pustule formation in Behcet's syndrome. SN - 0012-0472 UR - https://www.unboundmedicine.com/medline/citation/6851872/[The_sterile_Behçet_pustule:_a_typical_skin_manifestation_of_the_Behçet_syndrome]_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2008-1069648 DB - PRIME DP - Unbound Medicine ER -