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Complement consumption and IgE binding by house dust allergen in the serum of atopic patients.
Allergol Immunopathol (Madr). 1978 Jan-Feb; 6(1):45-54.AI

Abstract

The reactivity of complement (C) with housedust allergen has been investigated in separate groups of sera from atopic patients with seasonal hay fever, bronchial asthma, atopic dermatitis, animal dander allergy or asthmatic bronchitis as compared to controls. Complement consumption was more pronounced on average in the allergy groups, with the exception of atopic dermatitis. Total IgE levels were elevated in all groups, especially in atopic dermatitis. There was no correlation between C-sensitivity and IgE data (RAST and RIST). The mean levels of C1-inhibitor, 1-antitrypsin and 2-marcroglobulin in the atopic group were found normal. A significant correlation was found between the extent of C-consumption by house dust allergen and the level of C4 in sera. It is concluded that both C and IgE differ from normal in atopic patients, but that neither one is suited for the routine diagnosis of atopy in individual serum samples.

Authors

Berrens L
No affiliation info available
Schoonenwolf DA
No affiliation info available
Bruynzeel PL
No affiliation info available

MeSH

AdultAllergensAsthmaComplement System ProteinsDermatitis, AtopicDustEczemaHumansHypersensitivityImmunoglobulin EProtein BindingRhinitis, Allergic, Seasonal

Pub Type(s)

Journal Article

Language

eng

PubMed ID

685790

Citation

Berrens, L, et al. "Complement Consumption and IgE Binding By House Dust Allergen in the Serum of Atopic Patients." Allergologia Et Immunopathologia, vol. 6, no. 1, 1978, pp. 45-54.
Berrens L, Schoonenwolf DA, Bruynzeel PL. Complement consumption and IgE binding by house dust allergen in the serum of atopic patients. Allergol Immunopathol (Madr). 1978;6(1):45-54.
Berrens, L., Schoonenwolf, D. A., & Bruynzeel, P. L. (1978). Complement consumption and IgE binding by house dust allergen in the serum of atopic patients. Allergologia Et Immunopathologia, 6(1), 45-54.
Berrens L, Schoonenwolf DA, Bruynzeel PL. Complement Consumption and IgE Binding By House Dust Allergen in the Serum of Atopic Patients. Allergol Immunopathol (Madr). 1978 Jan-Feb;6(1):45-54. PubMed PMID: 685790.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Complement consumption and IgE binding by house dust allergen in the serum of atopic patients. AU - Berrens,L, AU - Schoonenwolf,D A, AU - Bruynzeel,P L, PY - 1978/1/1/pubmed PY - 1978/1/1/medline PY - 1978/1/1/entrez SP - 45 EP - 54 JF - Allergologia et immunopathologia JO - Allergol Immunopathol (Madr) VL - 6 IS - 1 N2 - The reactivity of complement (C) with housedust allergen has been investigated in separate groups of sera from atopic patients with seasonal hay fever, bronchial asthma, atopic dermatitis, animal dander allergy or asthmatic bronchitis as compared to controls. Complement consumption was more pronounced on average in the allergy groups, with the exception of atopic dermatitis. Total IgE levels were elevated in all groups, especially in atopic dermatitis. There was no correlation between C-sensitivity and IgE data (RAST and RIST). The mean levels of C1-inhibitor, 1-antitrypsin and 2-marcroglobulin in the atopic group were found normal. A significant correlation was found between the extent of C-consumption by house dust allergen and the level of C4 in sera. It is concluded that both C and IgE differ from normal in atopic patients, but that neither one is suited for the routine diagnosis of atopy in individual serum samples. SN - 0301-0546 UR - https://www.unboundmedicine.com/medline/citation/685790/Complement_consumption_and_IgE_binding_by_house_dust_allergen_in_the_serum_of_atopic_patients_ DB - PRIME DP - Unbound Medicine ER -