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Chronic ethanol administration induced an increase in phosphatidylserine in guinea pig synaptic plasma membranes.
Biochem Biophys Res Commun. 1983 May 31; 113(1):262-8.BB

Abstract

Chronic ethanol administration to guinea pigs via intragastric intubation elicited a specific increase (50%) in phosphatidylserine in the synaptic plasma membrane. The ethanol-treated group also showed a 53% increase in synaptosomal (Na,K)-ATPase activity. Analysis of the acyl group composition of individual phospholipids in the same membrane fraction revealed only small changes which varied depending on the type of phospholipids. Since the (Na,K)-ATPase is known to be specifically activated by phosphatidylserine, the adaptive increase in enzyme activity during chronic ethanol treatment may be related to the increase in this type of negatively charged phospholipid.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

6860339

Citation

Sun, G Y., and A Y. Sun. "Chronic Ethanol Administration Induced an Increase in Phosphatidylserine in Guinea Pig Synaptic Plasma Membranes." Biochemical and Biophysical Research Communications, vol. 113, no. 1, 1983, pp. 262-8.
Sun GY, Sun AY. Chronic ethanol administration induced an increase in phosphatidylserine in guinea pig synaptic plasma membranes. Biochem Biophys Res Commun. 1983;113(1):262-8.
Sun, G. Y., & Sun, A. Y. (1983). Chronic ethanol administration induced an increase in phosphatidylserine in guinea pig synaptic plasma membranes. Biochemical and Biophysical Research Communications, 113(1), 262-8.
Sun GY, Sun AY. Chronic Ethanol Administration Induced an Increase in Phosphatidylserine in Guinea Pig Synaptic Plasma Membranes. Biochem Biophys Res Commun. 1983 May 31;113(1):262-8. PubMed PMID: 6860339.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chronic ethanol administration induced an increase in phosphatidylserine in guinea pig synaptic plasma membranes. AU - Sun,G Y, AU - Sun,A Y, PY - 1983/5/31/pubmed PY - 1983/5/31/medline PY - 1983/5/31/entrez SP - 262 EP - 8 JF - Biochemical and biophysical research communications JO - Biochem Biophys Res Commun VL - 113 IS - 1 N2 - Chronic ethanol administration to guinea pigs via intragastric intubation elicited a specific increase (50%) in phosphatidylserine in the synaptic plasma membrane. The ethanol-treated group also showed a 53% increase in synaptosomal (Na,K)-ATPase activity. Analysis of the acyl group composition of individual phospholipids in the same membrane fraction revealed only small changes which varied depending on the type of phospholipids. Since the (Na,K)-ATPase is known to be specifically activated by phosphatidylserine, the adaptive increase in enzyme activity during chronic ethanol treatment may be related to the increase in this type of negatively charged phospholipid. SN - 0006-291X UR - https://www.unboundmedicine.com/medline/citation/6860339/Chronic_ethanol_administration_induced_an_increase_in_phosphatidylserine_in_guinea_pig_synaptic_plasma_membranes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0006-291X(83)90460-6 DB - PRIME DP - Unbound Medicine ER -