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The epidemiology of endometrial cancer in young women.
Br J Cancer. 1983 Jun; 47(6):749-56.BJ

Abstract

A case-control study was conducted in Los Angeles County, California, of 127 endometrial cancer cases aged 45 years or less at diagnosis, to investigate the role of fertility, obesity and exogenous oestrogens in the development of the disease in young women. Use of sequential oral contraceptive (SOCs) or oestrogen replacement therapy (ERT) for greater than or equal to 2 years was strongly associated with increased risk of endometrial cancer. After excluding these cases, since the SOC or ERT use was probably the cause of their disease, we were left with 110 case-control pairs for further study. Among these remaining case-control pairs increasing parity was strongly associated with decreased risk (relative risk of 0.12 for women of parity 3 compared to nulliparous women, P less than 0.001). Current weight was associated with increased risk (relative risk of 17.7 for women weighing greater than or equal to 190 lbs compared to women weighing less than 130 lbs, P less than 0.001). Combination oral contraceptive (COC) use was associated with a decreased risk, which decreased with duration of COC use (relative risk of approximately 0.28 at 5 years of use, P less than 0.001), but the estimate of the protective effect was reduced and became statistically non-significant when allowance was made for weight and parity. The protective effect of COC use was only clearly evident in women who had less than 3 live-births and weighed less than 170 lbs. These results provide further support for the "unopposed" oestrogen hypothesis of the aetiology of endometrial cancer.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

6860544

Citation

Henderson, B E., et al. "The Epidemiology of Endometrial Cancer in Young Women." British Journal of Cancer, vol. 47, no. 6, 1983, pp. 749-56.
Henderson BE, Casagrande JT, Pike MC, et al. The epidemiology of endometrial cancer in young women. Br J Cancer. 1983;47(6):749-56.
Henderson, B. E., Casagrande, J. T., Pike, M. C., Mack, T., Rosario, I., & Duke, A. (1983). The epidemiology of endometrial cancer in young women. British Journal of Cancer, 47(6), 749-56.
Henderson BE, et al. The Epidemiology of Endometrial Cancer in Young Women. Br J Cancer. 1983;47(6):749-56. PubMed PMID: 6860544.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The epidemiology of endometrial cancer in young women. AU - Henderson,B E, AU - Casagrande,J T, AU - Pike,M C, AU - Mack,T, AU - Rosario,I, AU - Duke,A, PY - 1983/6/1/pubmed PY - 1983/6/1/medline PY - 1983/6/1/entrez KW - Age Factors KW - Amenorrhea KW - Biology KW - Body Weight KW - Cancer KW - Contraception KW - Contraceptive Agents KW - Contraceptive Agents, Female KW - Contraceptive Methods--side effects KW - Control Groups KW - Data Collection KW - Diseases KW - Endocrine System KW - Endometrial Cancer KW - Estrogens--side effects KW - Family Planning KW - High Risk Women KW - Hormones KW - Infertility KW - Neoplasms KW - Oral Contraceptives, Combined KW - Oral Contraceptives, Phasic KW - Oral Contraceptives--side effects KW - Physiology KW - Reproduction KW - Reproductive Control Agents KW - Research Methodology KW - Socioeconomic Status KW - Women SP - 749 EP - 56 JF - British journal of cancer JO - Br J Cancer VL - 47 IS - 6 N2 - A case-control study was conducted in Los Angeles County, California, of 127 endometrial cancer cases aged 45 years or less at diagnosis, to investigate the role of fertility, obesity and exogenous oestrogens in the development of the disease in young women. Use of sequential oral contraceptive (SOCs) or oestrogen replacement therapy (ERT) for greater than or equal to 2 years was strongly associated with increased risk of endometrial cancer. After excluding these cases, since the SOC or ERT use was probably the cause of their disease, we were left with 110 case-control pairs for further study. Among these remaining case-control pairs increasing parity was strongly associated with decreased risk (relative risk of 0.12 for women of parity 3 compared to nulliparous women, P less than 0.001). Current weight was associated with increased risk (relative risk of 17.7 for women weighing greater than or equal to 190 lbs compared to women weighing less than 130 lbs, P less than 0.001). Combination oral contraceptive (COC) use was associated with a decreased risk, which decreased with duration of COC use (relative risk of approximately 0.28 at 5 years of use, P less than 0.001), but the estimate of the protective effect was reduced and became statistically non-significant when allowance was made for weight and parity. The protective effect of COC use was only clearly evident in women who had less than 3 live-births and weighed less than 170 lbs. These results provide further support for the "unopposed" oestrogen hypothesis of the aetiology of endometrial cancer. SN - 0007-0920 UR - https://www.unboundmedicine.com/medline/citation/6860544/The_epidemiology_of_endometrial_cancer_in_young_women_ L2 - https://doi.org/10.1038/bjc.1983.127 DB - PRIME DP - Unbound Medicine ER -