Tags

Type your tag names separated by a space and hit enter

Decrease in theophylline clearance after the administration of erythromycin to a patient with obstructive lung disease.
Drug Intell Clin Pharm. 1983 May; 17(5):370-2.DI

Abstract

It has been demonstrated previously that erythromycin can inhibit the total body clearance of theophylline, resulting in elevated serum theophylline concentrations. The overall incidence of this interaction and the population at risk have not been elucidated fully. Recent investigations have suggested that such an interaction is doubtful and that patients in whom this occurrence was suspect developed alterations in theophylline disposition secondary to worsening pulmonary function, not from erythromycin therapy alone. This case report shows that the interaction between theophylline and erythromycin can be clinically significant, producing as much as a 50-percent reduction in the total body clearance of the bronchodilator. The magnitude and time course of this interaction in patients with congestive heart failure and chronic obstructive pulmonary disease may differ considerably from that reported in healthy volunteers.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

6861626

Citation

Green, J A., and W A. Clementi. "Decrease in Theophylline Clearance After the Administration of Erythromycin to a Patient With Obstructive Lung Disease." Drug Intelligence & Clinical Pharmacy, vol. 17, no. 5, 1983, pp. 370-2.
Green JA, Clementi WA. Decrease in theophylline clearance after the administration of erythromycin to a patient with obstructive lung disease. Drug Intell Clin Pharm. 1983;17(5):370-2.
Green, J. A., & Clementi, W. A. (1983). Decrease in theophylline clearance after the administration of erythromycin to a patient with obstructive lung disease. Drug Intelligence & Clinical Pharmacy, 17(5), 370-2.
Green JA, Clementi WA. Decrease in Theophylline Clearance After the Administration of Erythromycin to a Patient With Obstructive Lung Disease. Drug Intell Clin Pharm. 1983;17(5):370-2. PubMed PMID: 6861626.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Decrease in theophylline clearance after the administration of erythromycin to a patient with obstructive lung disease. AU - Green,J A, AU - Clementi,W A, PY - 1983/5/1/pubmed PY - 1983/5/1/medline PY - 1983/5/1/entrez SP - 370 EP - 2 JF - Drug intelligence & clinical pharmacy JO - Drug Intell Clin Pharm VL - 17 IS - 5 N2 - It has been demonstrated previously that erythromycin can inhibit the total body clearance of theophylline, resulting in elevated serum theophylline concentrations. The overall incidence of this interaction and the population at risk have not been elucidated fully. Recent investigations have suggested that such an interaction is doubtful and that patients in whom this occurrence was suspect developed alterations in theophylline disposition secondary to worsening pulmonary function, not from erythromycin therapy alone. This case report shows that the interaction between theophylline and erythromycin can be clinically significant, producing as much as a 50-percent reduction in the total body clearance of the bronchodilator. The magnitude and time course of this interaction in patients with congestive heart failure and chronic obstructive pulmonary disease may differ considerably from that reported in healthy volunteers. SN - 0012-6578 UR - https://www.unboundmedicine.com/medline/citation/6861626/Decrease_in_theophylline_clearance_after_the_administration_of_erythromycin_to_a_patient_with_obstructive_lung_disease_ DB - PRIME DP - Unbound Medicine ER -