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The effects of using different grades of PVP and gelatin as binders in the fluidized bed granulation and tabletting of lactose.
Pharmazie. 1983 Apr; 38(4):240-3.P

Abstract

The effects of using different grades of PVP and gelatin binders on three sieve fractions of lactose granulated in a fluidized bed granulator and tablets have been studied. Increasing the molecular mass of PVP or bloom number of gelatin resulted in a decrease in granule friability but in an increase in their average size and porosity and in the tensile strengths of the resulting tablets when compressed to a fixed apparent density. The results have been explained in terms of the effects of moist and dry binder bridges on bonding of particles in granules and tablets.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

6867086

Citation

Georgakopoulos, P P., et al. "The Effects of Using Different Grades of PVP and Gelatin as Binders in the Fluidized Bed Granulation and Tabletting of Lactose." Die Pharmazie, vol. 38, no. 4, 1983, pp. 240-3.
Georgakopoulos PP, Malamataris S, Dolamidis G. The effects of using different grades of PVP and gelatin as binders in the fluidized bed granulation and tabletting of lactose. Pharmazie. 1983;38(4):240-3.
Georgakopoulos, P. P., Malamataris, S., & Dolamidis, G. (1983). The effects of using different grades of PVP and gelatin as binders in the fluidized bed granulation and tabletting of lactose. Die Pharmazie, 38(4), 240-3.
Georgakopoulos PP, Malamataris S, Dolamidis G. The Effects of Using Different Grades of PVP and Gelatin as Binders in the Fluidized Bed Granulation and Tabletting of Lactose. Pharmazie. 1983;38(4):240-3. PubMed PMID: 6867086.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of using different grades of PVP and gelatin as binders in the fluidized bed granulation and tabletting of lactose. AU - Georgakopoulos,P P, AU - Malamataris,S, AU - Dolamidis,G, PY - 1983/4/1/pubmed PY - 1983/4/1/medline PY - 1983/4/1/entrez SP - 240 EP - 3 JF - Die Pharmazie JO - Pharmazie VL - 38 IS - 4 N2 - The effects of using different grades of PVP and gelatin binders on three sieve fractions of lactose granulated in a fluidized bed granulator and tablets have been studied. Increasing the molecular mass of PVP or bloom number of gelatin resulted in a decrease in granule friability but in an increase in their average size and porosity and in the tensile strengths of the resulting tablets when compressed to a fixed apparent density. The results have been explained in terms of the effects of moist and dry binder bridges on bonding of particles in granules and tablets. SN - 0031-7144 UR - https://www.unboundmedicine.com/medline/citation/6867086/The_effects_of_using_different_grades_of_PVP_and_gelatin_as_binders_in_the_fluidized_bed_granulation_and_tabletting_of_lactose_ L2 - https://www.lens.org/lens/search/patent/list?q=citation_id:6867086 DB - PRIME DP - Unbound Medicine ER -