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Arachidonate induced aggregation of rat platelets may not require prostaglandin endoperoxides or thromboxane A2.
Thromb Res. 1983 May 01; 30(3):289-96.TR

Abstract

Platelet aggregation was measured in rat and human platelet-rich plasma (PRP) after the addition of various amounts of arachidonic acid (AA), prostaglandin H2 (PGH2), adenosine diphosphate (ADP), or collagen. AA but not PGH2 caused rat platelets to aggregate in citrated or heparinized PRP. Both AA and PGH2 produced significant amounts of thromboxane A2 (TxA2) measured as thromboxane B2 (TxB2). The lack of aggregation of rat platelets with PGH2 was not due to the formation of an inhibitor of aggregation such as a prostaglandin. Thus, the formation of TxA2 may not be necessary for aggregation of rat platelets. Human platelets were aggregated by PGH2 with the concomitant formation of TxB2.

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Authors

Nishizawa EE
No affiliation info available
Williams DJ
No affiliation info available
Connell CL
No affiliation info available

MeSH

AnimalsArachidonic AcidsMaleMethacrylatesPlatelet AggregationProstaglandin EndoperoxidesRatsRats, Inbred StrainsThromboxane A2Thromboxanes

Pub Type(s)

Journal Article

Language

eng

PubMed ID

6868025

Citation

Nishizawa, E E., et al. "Arachidonate Induced Aggregation of Rat Platelets May Not Require Prostaglandin Endoperoxides or Thromboxane A2." Thrombosis Research, vol. 30, no. 3, 1983, pp. 289-96.
Nishizawa EE, Williams DJ, Connell CL. Arachidonate induced aggregation of rat platelets may not require prostaglandin endoperoxides or thromboxane A2. Thromb Res. 1983;30(3):289-96.
Nishizawa, E. E., Williams, D. J., & Connell, C. L. (1983). Arachidonate induced aggregation of rat platelets may not require prostaglandin endoperoxides or thromboxane A2. Thrombosis Research, 30(3), 289-96.
Nishizawa EE, Williams DJ, Connell CL. Arachidonate Induced Aggregation of Rat Platelets May Not Require Prostaglandin Endoperoxides or Thromboxane A2. Thromb Res. 1983 May 1;30(3):289-96. PubMed PMID: 6868025.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Arachidonate induced aggregation of rat platelets may not require prostaglandin endoperoxides or thromboxane A2. AU - Nishizawa,E E, AU - Williams,D J, AU - Connell,C L, PY - 1983/5/1/pubmed PY - 1983/5/1/medline PY - 1983/5/1/entrez SP - 289 EP - 96 JF - Thrombosis research JO - Thromb Res VL - 30 IS - 3 N2 - Platelet aggregation was measured in rat and human platelet-rich plasma (PRP) after the addition of various amounts of arachidonic acid (AA), prostaglandin H2 (PGH2), adenosine diphosphate (ADP), or collagen. AA but not PGH2 caused rat platelets to aggregate in citrated or heparinized PRP. Both AA and PGH2 produced significant amounts of thromboxane A2 (TxA2) measured as thromboxane B2 (TxB2). The lack of aggregation of rat platelets with PGH2 was not due to the formation of an inhibitor of aggregation such as a prostaglandin. Thus, the formation of TxA2 may not be necessary for aggregation of rat platelets. Human platelets were aggregated by PGH2 with the concomitant formation of TxB2. SN - 0049-3848 UR - https://www.unboundmedicine.com/medline/citation/6868025/Arachidonate_induced_aggregation_of_rat_platelets_may_not_require_prostaglandin_endoperoxides_or_thromboxane_A2_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0049-3848(83)90082-8 DB - PRIME DP - Unbound Medicine ER -