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Activity of some lysosomal hydrolases in the homogenates of transplantable melanotic and amelanotic melanoma in golden hamster (Mesocricetus auratus, Waterhouse).
Arch Geschwulstforsch. 1978; 48(3):198-201.AG

Abstract

Activity of arylsulphatase, beta-glucuronidase, cathepsin D, and acid phosphatase in the homogenates of melanotic and amelanotic melanoma was determined. The activity of these enzymes is higher in melanotic than in amelanotic melanoma. Respective values for melanotic and amelanotic tumours are: arylsulphatase 10,78 +/- 3,20, and 1,45 +/- 0,66 micron 4-nitrocatechole/mg protein/hr; beta-glucuronidase 11,10 +/- 1,40, and 9,98 +/- 1,35 micron phenolphthalein/mg protein/hr; cathepsin D 4,24 +/- 1,37, and 3,26 +/- 0,73 micron tyrosine/mg protein/hr; acid phosphatase 230 +/- 22, and 180 +/- 25 micron p-nitrophenol/mg protein/hr. These differences are statistically significant. The increased activity of the lysosomal enzymes in melantoic melanoma probably depends on the occurrence of an higher number of lysosomes in tissues containing melanins.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

686981

Citation

Drewa, G, et al. "Activity of some Lysosomal Hydrolases in the Homogenates of Transplantable Melanotic and Amelanotic Melanoma in Golden Hamster (Mesocricetus Auratus, Waterhouse)." Archiv Fur Geschwulstforschung, vol. 48, no. 3, 1978, pp. 198-201.
Drewa G, Zbytniewski Z, Kanclerz A. Activity of some lysosomal hydrolases in the homogenates of transplantable melanotic and amelanotic melanoma in golden hamster (Mesocricetus auratus, Waterhouse). Arch Geschwulstforsch. 1978;48(3):198-201.
Drewa, G., Zbytniewski, Z., & Kanclerz, A. (1978). Activity of some lysosomal hydrolases in the homogenates of transplantable melanotic and amelanotic melanoma in golden hamster (Mesocricetus auratus, Waterhouse). Archiv Fur Geschwulstforschung, 48(3), 198-201.
Drewa G, Zbytniewski Z, Kanclerz A. Activity of some Lysosomal Hydrolases in the Homogenates of Transplantable Melanotic and Amelanotic Melanoma in Golden Hamster (Mesocricetus Auratus, Waterhouse). Arch Geschwulstforsch. 1978;48(3):198-201. PubMed PMID: 686981.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Activity of some lysosomal hydrolases in the homogenates of transplantable melanotic and amelanotic melanoma in golden hamster (Mesocricetus auratus, Waterhouse). AU - Drewa,G, AU - Zbytniewski,Z, AU - Kanclerz,A, PY - 1978/1/1/pubmed PY - 1978/1/1/medline PY - 1978/1/1/entrez SP - 198 EP - 201 JF - Archiv fur Geschwulstforschung JO - Arch Geschwulstforsch VL - 48 IS - 3 N2 - Activity of arylsulphatase, beta-glucuronidase, cathepsin D, and acid phosphatase in the homogenates of melanotic and amelanotic melanoma was determined. The activity of these enzymes is higher in melanotic than in amelanotic melanoma. Respective values for melanotic and amelanotic tumours are: arylsulphatase 10,78 +/- 3,20, and 1,45 +/- 0,66 micron 4-nitrocatechole/mg protein/hr; beta-glucuronidase 11,10 +/- 1,40, and 9,98 +/- 1,35 micron phenolphthalein/mg protein/hr; cathepsin D 4,24 +/- 1,37, and 3,26 +/- 0,73 micron tyrosine/mg protein/hr; acid phosphatase 230 +/- 22, and 180 +/- 25 micron p-nitrophenol/mg protein/hr. These differences are statistically significant. The increased activity of the lysosomal enzymes in melantoic melanoma probably depends on the occurrence of an higher number of lysosomes in tissues containing melanins. SN - 0003-911X UR - https://www.unboundmedicine.com/medline/citation/686981/Activity_of_some_lysosomal_hydrolases_in_the_homogenates_of_transplantable_melanotic_and_amelanotic_melanoma_in_golden_hamster__Mesocricetus_auratus_Waterhouse__ L2 - https://medlineplus.gov/melanoma.html DB - PRIME DP - Unbound Medicine ER -