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Nerve conduction in leprosy: in vivo and in vitro study.
Lepr India. 1983 Jan; 55(1):12-21.LI

Abstract

Sensory and mixed nerve conduction studies were performed on the distal segments of the radial, sural, median and ulnar nerves of leprosy patients from the entire spectrum of the disease. The values obtained were compared with those of age matched normal controls. All the clinically involved nerves, and about 30% of the clinically normal patient nerves showed a delayed conduction velocity. The conduction velocity difference was most significant (P less than 0.001) for the cutaneous branch of the radial, and sural nerves as compared to the ulnar and median. Five patients nerves that were clinically normal and showed a normal conduction velocity when tested in vivo, were biopsies and studied in vitro to determine the type of early nerve damage. C and A delta fibre involvement was found in all these nerves. It is concluded that leprosy is a diffuse neuropathy and there is early detectable nerve involvement even in clinically normal nerves of leprosy patients.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6876754

Citation

Donde, S V., et al. "Nerve Conduction in Leprosy: in Vivo and in Vitro Study." Leprosy in India, vol. 55, no. 1, 1983, pp. 12-21.
Donde SV, Shah A, Antia NH. Nerve conduction in leprosy: in vivo and in vitro study. Lepr India. 1983;55(1):12-21.
Donde, S. V., Shah, A., & Antia, N. H. (1983). Nerve conduction in leprosy: in vivo and in vitro study. Leprosy in India, 55(1), 12-21.
Donde SV, Shah A, Antia NH. Nerve Conduction in Leprosy: in Vivo and in Vitro Study. Lepr India. 1983;55(1):12-21. PubMed PMID: 6876754.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nerve conduction in leprosy: in vivo and in vitro study. AU - Donde,S V, AU - Shah,A, AU - Antia,N H, PY - 1983/1/1/pubmed PY - 1983/1/1/medline PY - 1983/1/1/entrez SP - 12 EP - 21 JF - Leprosy in India JO - Lepr India VL - 55 IS - 1 N2 - Sensory and mixed nerve conduction studies were performed on the distal segments of the radial, sural, median and ulnar nerves of leprosy patients from the entire spectrum of the disease. The values obtained were compared with those of age matched normal controls. All the clinically involved nerves, and about 30% of the clinically normal patient nerves showed a delayed conduction velocity. The conduction velocity difference was most significant (P less than 0.001) for the cutaneous branch of the radial, and sural nerves as compared to the ulnar and median. Five patients nerves that were clinically normal and showed a normal conduction velocity when tested in vivo, were biopsies and studied in vitro to determine the type of early nerve damage. C and A delta fibre involvement was found in all these nerves. It is concluded that leprosy is a diffuse neuropathy and there is early detectable nerve involvement even in clinically normal nerves of leprosy patients. SN - 0024-1024 UR - https://www.unboundmedicine.com/medline/citation/6876754/Nerve_conduction_in_leprosy:_in_vivo_and_in_vitro_study_ L2 - https://medlineplus.gov/mycobacterialinfections.html DB - PRIME DP - Unbound Medicine ER -