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Nucleation of cholesterol monohydrate crystals from hepatic and gall-bladder bile of patients with cholesterol gall stones.
Gut 1983; 24(9):836-44Gut

Abstract

Nucleation time and cholesterol saturation index of hepatic and gall-bladder bile were measured in 16 patients with cholesterol gall stones to determine whether a gall bladder or liver defect was responsible for the rapid nucleation time of gall-bladder bile in such patients. Although hepatic bile was consistently more saturated than gall-bladder bile, the in vitro nucleation time of gall-bladder bile was more rapid. Dilution of gall-bladder bile to hepatic bile concentrations did not affect nucleation time. The results indicate that the gall bladder plays an important role in the production of the rapidly nucleating bile which is found in patients with cholesterol gall stones, and that this role is not simply concentration of bile by the gall bladder. Normal and abnormal gall-bladder biles were also compared in a larger group of patients. The view that there is a nucleation defect in cholesterol cholelithiasis which is independent of cholesterol saturation was confirmed. Subgroups of normal and gall-stone population were defined by the nucleation time and saturation index. Results suggested that solitary stones may be produced under different conditions than multiple stones. Some putative nucleating factors were examined but none was found to distinguish between normal and gall-stone bile.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6884818

Citation

Gollish, S H., et al. "Nucleation of Cholesterol Monohydrate Crystals From Hepatic and Gall-bladder Bile of Patients With Cholesterol Gall Stones." Gut, vol. 24, no. 9, 1983, pp. 836-44.
Gollish SH, Burnstein MJ, Ilson RG, et al. Nucleation of cholesterol monohydrate crystals from hepatic and gall-bladder bile of patients with cholesterol gall stones. Gut. 1983;24(9):836-44.
Gollish, S. H., Burnstein, M. J., Ilson, R. G., Petrunka, C. N., & Strasberg, S. M. (1983). Nucleation of cholesterol monohydrate crystals from hepatic and gall-bladder bile of patients with cholesterol gall stones. Gut, 24(9), pp. 836-44.
Gollish SH, et al. Nucleation of Cholesterol Monohydrate Crystals From Hepatic and Gall-bladder Bile of Patients With Cholesterol Gall Stones. Gut. 1983;24(9):836-44. PubMed PMID: 6884818.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nucleation of cholesterol monohydrate crystals from hepatic and gall-bladder bile of patients with cholesterol gall stones. AU - Gollish,S H, AU - Burnstein,M J, AU - Ilson,R G, AU - Petrunka,C N, AU - Strasberg,S M, PY - 1983/9/1/pubmed PY - 1983/9/1/medline PY - 1983/9/1/entrez SP - 836 EP - 44 JF - Gut JO - Gut VL - 24 IS - 9 N2 - Nucleation time and cholesterol saturation index of hepatic and gall-bladder bile were measured in 16 patients with cholesterol gall stones to determine whether a gall bladder or liver defect was responsible for the rapid nucleation time of gall-bladder bile in such patients. Although hepatic bile was consistently more saturated than gall-bladder bile, the in vitro nucleation time of gall-bladder bile was more rapid. Dilution of gall-bladder bile to hepatic bile concentrations did not affect nucleation time. The results indicate that the gall bladder plays an important role in the production of the rapidly nucleating bile which is found in patients with cholesterol gall stones, and that this role is not simply concentration of bile by the gall bladder. Normal and abnormal gall-bladder biles were also compared in a larger group of patients. The view that there is a nucleation defect in cholesterol cholelithiasis which is independent of cholesterol saturation was confirmed. Subgroups of normal and gall-stone population were defined by the nucleation time and saturation index. Results suggested that solitary stones may be produced under different conditions than multiple stones. Some putative nucleating factors were examined but none was found to distinguish between normal and gall-stone bile. SN - 0017-5749 UR - https://www.unboundmedicine.com/medline/citation/6884818/Nucleation_of_cholesterol_monohydrate_crystals_from_hepatic_and_gall_bladder_bile_of_patients_with_cholesterol_gall_stones_ L2 - http://gut.bmj.com/cgi/pmidlookup?view=long&pmid=6884818 DB - PRIME DP - Unbound Medicine ER -