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Screening of host-mediated antitumor polysaccharides by crossed immunoelectrophoresis using fresh human serum.
Jpn J Pharmacol. 1983 Apr; 33(2):403-8.JJ

Abstract

On crossed immunoelectrophoresis, human serum C3 (the third component of complement) converted by antitumor polysaccharides (ATSO [antitumor polysaccharide oral], AB-P [Agaricaus blazei polysaccharide], GU-P [Grifora umbellata polysaccharide], PS-K [polysaccharide Kureha] and zymosan) moved faster than native C3, appearing as the 3rd peak. The ratio of height of the 3rd peak to the alpha 2-macroglobulin (alpha 2-M) peak was linearly proportional to the dose of ATSO. At the dose of 500 micrograms/ml antitumor polysaccharides, the ratios were higher than 0.76, and the ratios for the serum treated with polysaccharide of no antitumor activity (dextran and gum arabic) were less than about 0.52. This ratio readily determined in vivo can be used as a measure for the antitumor activity of polysaccharides.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

6887647

Citation

Shimura, K, et al. "Screening of Host-mediated Antitumor Polysaccharides By Crossed Immunoelectrophoresis Using Fresh Human Serum." Japanese Journal of Pharmacology, vol. 33, no. 2, 1983, pp. 403-8.
Shimura K, Ito H, Hibasami H. Screening of host-mediated antitumor polysaccharides by crossed immunoelectrophoresis using fresh human serum. Jpn J Pharmacol. 1983;33(2):403-8.
Shimura, K., Ito, H., & Hibasami, H. (1983). Screening of host-mediated antitumor polysaccharides by crossed immunoelectrophoresis using fresh human serum. Japanese Journal of Pharmacology, 33(2), 403-8.
Shimura K, Ito H, Hibasami H. Screening of Host-mediated Antitumor Polysaccharides By Crossed Immunoelectrophoresis Using Fresh Human Serum. Jpn J Pharmacol. 1983;33(2):403-8. PubMed PMID: 6887647.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Screening of host-mediated antitumor polysaccharides by crossed immunoelectrophoresis using fresh human serum. AU - Shimura,K, AU - Ito,H, AU - Hibasami,H, PY - 1983/4/1/pubmed PY - 1983/4/1/medline PY - 1983/4/1/entrez SP - 403 EP - 8 JF - Japanese journal of pharmacology JO - Jpn J Pharmacol VL - 33 IS - 2 N2 - On crossed immunoelectrophoresis, human serum C3 (the third component of complement) converted by antitumor polysaccharides (ATSO [antitumor polysaccharide oral], AB-P [Agaricaus blazei polysaccharide], GU-P [Grifora umbellata polysaccharide], PS-K [polysaccharide Kureha] and zymosan) moved faster than native C3, appearing as the 3rd peak. The ratio of height of the 3rd peak to the alpha 2-macroglobulin (alpha 2-M) peak was linearly proportional to the dose of ATSO. At the dose of 500 micrograms/ml antitumor polysaccharides, the ratios were higher than 0.76, and the ratios for the serum treated with polysaccharide of no antitumor activity (dextran and gum arabic) were less than about 0.52. This ratio readily determined in vivo can be used as a measure for the antitumor activity of polysaccharides. SN - 0021-5198 UR - https://www.unboundmedicine.com/medline/citation/6887647/Screening_of_host_mediated_antitumor_polysaccharides_by_crossed_immunoelectrophoresis_using_fresh_human_serum_ L2 - https://joi.jlc.jst.go.jp/JST.Journalarchive/jphs1951/33.403?from=PubMed DB - PRIME DP - Unbound Medicine ER -