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Distribution of axonal transport blockade by acute intraocular pressure elevation in the primate optic nerve head.
Invest Ophthalmol Vis Sci. 1977 Jul; 16(7):640-4.IO

Abstract

We studied the degree of axonal transport blockade in various areas of the optic nerve head with acute intraocular pressure (IOP) elevation in 19 squirrel monkey eyes. When IOP was raised to 20 to 50 mm. Hg for 7 hr., mild axonal transport blockade occurred in each area of the disk, most prominently in nerve fiber bundles of the superior pole. With 7 hr. IOP elevations between 50 and 90 mm. Hg, a somewhat greater degree of transport blockade occurred throughout the nerve head, although again the superior and inferior poles were somewhat more affected. The distribution of short-term transport blockade over the entire nerve head corresponds to the diffuse damage of acute glaucoma, but the pattern hints at the preference for damage near the poles of the disk seen in chronic glaucoma. However, before these results can be fully evaluated, further information is needed on axonal pathways through the optic nerve head and on the relationship between transport obstruction and ganglion cell death.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

68942

Citation

Quigley, H A., and D R. Anderson. "Distribution of Axonal Transport Blockade By Acute Intraocular Pressure Elevation in the Primate Optic Nerve Head." Investigative Ophthalmology & Visual Science, vol. 16, no. 7, 1977, pp. 640-4.
Quigley HA, Anderson DR. Distribution of axonal transport blockade by acute intraocular pressure elevation in the primate optic nerve head. Invest Ophthalmol Vis Sci. 1977;16(7):640-4.
Quigley, H. A., & Anderson, D. R. (1977). Distribution of axonal transport blockade by acute intraocular pressure elevation in the primate optic nerve head. Investigative Ophthalmology & Visual Science, 16(7), 640-4.
Quigley HA, Anderson DR. Distribution of Axonal Transport Blockade By Acute Intraocular Pressure Elevation in the Primate Optic Nerve Head. Invest Ophthalmol Vis Sci. 1977;16(7):640-4. PubMed PMID: 68942.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Distribution of axonal transport blockade by acute intraocular pressure elevation in the primate optic nerve head. AU - Quigley,H A, AU - Anderson,D R, PY - 1977/7/1/pubmed PY - 1977/7/1/medline PY - 1977/7/1/entrez SP - 640 EP - 4 JF - Investigative ophthalmology & visual science JO - Invest Ophthalmol Vis Sci VL - 16 IS - 7 N2 - We studied the degree of axonal transport blockade in various areas of the optic nerve head with acute intraocular pressure (IOP) elevation in 19 squirrel monkey eyes. When IOP was raised to 20 to 50 mm. Hg for 7 hr., mild axonal transport blockade occurred in each area of the disk, most prominently in nerve fiber bundles of the superior pole. With 7 hr. IOP elevations between 50 and 90 mm. Hg, a somewhat greater degree of transport blockade occurred throughout the nerve head, although again the superior and inferior poles were somewhat more affected. The distribution of short-term transport blockade over the entire nerve head corresponds to the diffuse damage of acute glaucoma, but the pattern hints at the preference for damage near the poles of the disk seen in chronic glaucoma. However, before these results can be fully evaluated, further information is needed on axonal pathways through the optic nerve head and on the relationship between transport obstruction and ganglion cell death. SN - 0146-0404 UR - https://www.unboundmedicine.com/medline/citation/68942/Distribution_of_axonal_transport_blockade_by_acute_intraocular_pressure_elevation_in_the_primate_optic_nerve_head_ L2 - https://iovs.arvojournals.org/article.aspx?volume=16&issue=7&page=640 DB - PRIME DP - Unbound Medicine ER -