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Studies of thyroid hormone and methimazole levels in patients with Graves' disease on a standardized anti-thyroid drug regimen.
Clin Endocrinol (Oxf). 1981 Jun; 14(6):555-62.CE

Abstract

The outcome of a standardized carbimazole (CMI) regimen was evaluated in fifty-four patients with Graves' disease. Triiodothyronine (T3) and thyroxine (T4) serum values were determined before and throughout the first 6-8 months of therapy. Before therapy, decreasing T4/T3 ratios were found with increasing T3 levels, reflecting a relative increase in T3 production compared with T4 in thyrotoxicosis. High pretreatment T3 values were comparatively common among patients in whom a fixed CMI dosage had a insufficient effect. T4 levels were less informative in this respect. Serum levels of methimazole (MMI), the active metabolite of CMI, were dose-dependent. A 50% reduction in dosage resulted in a similar decrease in the serum values. For a give dose, the MMI levels differed considerably among individuals. The variation was not related to thyroid hormone values. It appears that the response to the anti-thyroid drug is primarily dependent upon the severity of the disease, Which is clearly reflected in serum T3 levels, rather than individual differences in drug handling. A routine CMI regimen for the treatment of thyrotoxicosis is suggested.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6895351

Citation

Dahlberg, P A., et al. "Studies of Thyroid Hormone and Methimazole Levels in Patients With Graves' Disease On a Standardized Anti-thyroid Drug Regimen." Clinical Endocrinology, vol. 14, no. 6, 1981, pp. 555-62.
Dahlberg PA, Karlsson FA, Lindström B, et al. Studies of thyroid hormone and methimazole levels in patients with Graves' disease on a standardized anti-thyroid drug regimen. Clin Endocrinol (Oxf). 1981;14(6):555-62.
Dahlberg, P. A., Karlsson, F. A., Lindström, B., & Wide, L. (1981). Studies of thyroid hormone and methimazole levels in patients with Graves' disease on a standardized anti-thyroid drug regimen. Clinical Endocrinology, 14(6), 555-62.
Dahlberg PA, et al. Studies of Thyroid Hormone and Methimazole Levels in Patients With Graves' Disease On a Standardized Anti-thyroid Drug Regimen. Clin Endocrinol (Oxf). 1981;14(6):555-62. PubMed PMID: 6895351.
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TY - JOUR T1 - Studies of thyroid hormone and methimazole levels in patients with Graves' disease on a standardized anti-thyroid drug regimen. AU - Dahlberg,P A, AU - Karlsson,F A, AU - Lindström,B, AU - Wide,L, PY - 1981/6/1/pubmed PY - 1981/6/1/medline PY - 1981/6/1/entrez SP - 555 EP - 62 JF - Clinical endocrinology JO - Clin. Endocrinol. (Oxf) VL - 14 IS - 6 N2 - The outcome of a standardized carbimazole (CMI) regimen was evaluated in fifty-four patients with Graves' disease. Triiodothyronine (T3) and thyroxine (T4) serum values were determined before and throughout the first 6-8 months of therapy. Before therapy, decreasing T4/T3 ratios were found with increasing T3 levels, reflecting a relative increase in T3 production compared with T4 in thyrotoxicosis. High pretreatment T3 values were comparatively common among patients in whom a fixed CMI dosage had a insufficient effect. T4 levels were less informative in this respect. Serum levels of methimazole (MMI), the active metabolite of CMI, were dose-dependent. A 50% reduction in dosage resulted in a similar decrease in the serum values. For a give dose, the MMI levels differed considerably among individuals. The variation was not related to thyroid hormone values. It appears that the response to the anti-thyroid drug is primarily dependent upon the severity of the disease, Which is clearly reflected in serum T3 levels, rather than individual differences in drug handling. A routine CMI regimen for the treatment of thyrotoxicosis is suggested. SN - 0300-0664 UR - https://www.unboundmedicine.com/medline/citation/6895351/Studies_of_thyroid_hormone_and_methimazole_levels_in_patients_with_Graves'_disease_on_a_standardized_anti_thyroid_drug_regimen_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0300-0664&date=1981&volume=14&issue=6&spage=555 DB - PRIME DP - Unbound Medicine ER -