TY - JOUR T1 - Isocitrate uptake and citrate production by rat ventral prostate fragments. AU - Franklin,R B, AU - Costello,L C, PY - 1978/7/1/pubmed PY - 1978/7/1/medline PY - 1978/7/1/entrez SP - 44 EP - 7 JF - Investigative urology JO - Invest Urol VL - 16 IS - 1 N2 - Prostatic aconitase was investigated utilizing fragments of rat ventral prostate. The rate of citrate formation from isocitrate was used as an index of aconitase activity. Inhibition of citrate formation from isocitrate by fluorocitrate indicated that aconitase activity was being measured. The results indicated that whereas both kidney and prostate formed citrate from isocitrate, the aconitase activity of prostate was independent of both medium isocitrate and citrate concentration. In addition the aconitase activity of prostate seemed to favor citrate formation to a much greater degree than kidney. The results showed that the aconitase catalyzed conversion of citrate to isocitrate is limited in prostate and suggested that the deficient citrate oxidation observed in prostate is the result of a unique aconitase activity. SN - 0021-0005 UR - https://www.unboundmedicine.com/medline/citation/689836/Isocitrate_uptake_and_citrate_production_by_rat_ventral_prostate_fragments_ DB - PRIME DP - Unbound Medicine ER -