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Clinical characteristics and pathogenetic mechanisms in hyperuricosuric calcium oxalate renal stone disease.
Scand J Urol Nephrol Suppl. 1980; 53:171-7.SJ

Abstract

Studies of patients with hyperuricosuria have provided four kinds of evidence linking their hyperuricosuria to calcium stone formation and identifying them as a distinct entity apart from other calcium stone formers. The evidence includes a more virulent natural history of stone disease, in vitro evidence for heterogeneous nucleation of calcium oxalate crystallization by seed crystals for uric acid or sodium hydrogen urate, and a reduction by uric acid or urate of the inhibitory activity which urine normally has upon calcium oxalate crystal growth. The fourth bit of evidence, the dramatic reduction in stone formation rates with allopurinol treatment, will be discussed in detail in a following paper.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

6937993

Citation

Favus, M J., and F L. Coe. "Clinical Characteristics and Pathogenetic Mechanisms in Hyperuricosuric Calcium Oxalate Renal Stone Disease." Scandinavian Journal of Urology and Nephrology. Supplementum, vol. 53, 1980, pp. 171-7.
Favus MJ, Coe FL. Clinical characteristics and pathogenetic mechanisms in hyperuricosuric calcium oxalate renal stone disease. Scand J Urol Nephrol Suppl. 1980;53:171-7.
Favus, M. J., & Coe, F. L. (1980). Clinical characteristics and pathogenetic mechanisms in hyperuricosuric calcium oxalate renal stone disease. Scandinavian Journal of Urology and Nephrology. Supplementum, 53, 171-7.
Favus MJ, Coe FL. Clinical Characteristics and Pathogenetic Mechanisms in Hyperuricosuric Calcium Oxalate Renal Stone Disease. Scand J Urol Nephrol Suppl. 1980;53:171-7. PubMed PMID: 6937993.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical characteristics and pathogenetic mechanisms in hyperuricosuric calcium oxalate renal stone disease. AU - Favus,M J, AU - Coe,F L, PY - 1980/1/1/pubmed PY - 1980/1/1/medline PY - 1980/1/1/entrez SP - 171 EP - 7 JF - Scandinavian journal of urology and nephrology. Supplementum JO - Scand J Urol Nephrol Suppl VL - 53 N2 - Studies of patients with hyperuricosuria have provided four kinds of evidence linking their hyperuricosuria to calcium stone formation and identifying them as a distinct entity apart from other calcium stone formers. The evidence includes a more virulent natural history of stone disease, in vitro evidence for heterogeneous nucleation of calcium oxalate crystallization by seed crystals for uric acid or sodium hydrogen urate, and a reduction by uric acid or urate of the inhibitory activity which urine normally has upon calcium oxalate crystal growth. The fourth bit of evidence, the dramatic reduction in stone formation rates with allopurinol treatment, will be discussed in detail in a following paper. SN - 0300-8886 UR - https://www.unboundmedicine.com/medline/citation/6937993/Clinical_characteristics_and_pathogenetic_mechanisms_in_hyperuricosuric_calcium_oxalate_renal_stone_disease_ L2 - http://www.diseaseinfosearch.org/result/5518 DB - PRIME DP - Unbound Medicine ER -