TY - JOUR T1 - The effects of allopurinol treatment on stone formation on hyperuricosuric calcium oxalate stone-formers. AU - Favus,M J, AU - Coe,F L, PY - 1980/1/1/pubmed PY - 1980/1/1/medline PY - 1980/1/1/entrez SP - 265 EP - 71 JF - Scandinavian journal of urology and nephrology. Supplementum JO - Scand J Urol Nephrol Suppl VL - 53 N2 - The syndrome of hyperuricosuric calcium oxalate nephrolithiasis, consisting of calcium oxalate stones, hyperuricosuria and the absence of known causes of calcium stones, follows a course of particularly severe stone disease. This course can be dramatically altered by the reduction in new stone formation by the chronic administration of allopurinol. The mechanisms proposed in linking hyperuricosuria to calcium oxalate stones are both dependent upon the presence of oversaturation of the urine with one or both species of uric acid. Allopurinol reduces the saturation of the urine with respect to sodium hydrogen urate and reduces urine concentration of undissociated uric acid, thus directly altering the pathogenetic mechanisms proposed for this disorder. SN - 0300-8886 UR - https://www.unboundmedicine.com/medline/citation/6938003/The_effects_of_allopurinol_treatment_on_stone_formation_on_hyperuricosuric_calcium_oxalate_stone_formers_ DB - PRIME DP - Unbound Medicine ER -