Tags

Type your tag names separated by a space and hit enter

Filterability and vascular disease--I. Red cell filterability in diabetes mellitus: its relation to other methods of measuring deformability and to blood viscosity.

Abstract

Erythrocyte deformability, blood viscosity and other rheological variables were measured in 30 diabetics and 28 normal control subjects. Measurements of red cell rheology were made simultaneously by filtration of whole blood, centrifugation and viscometry of packed red cells. The diabetics showed a significant reduction of erythrocyte deformability measured by filtration, an increase in flexibility measured by centrifugation and values similar to normals for viscometry of packed red cells. Plasma viscosity but not whole blood viscosity (shear rates 23 and 230 s-1) was increased in the diabetics. Erythrocyte flexibility as measured by centrifugation was significantly related to blood viscosity and plasma fibrinogen and glucose in the diabetics, however, neither filtration nor viscometry of packed red cells correlated with other rheological variables. It seems likely that multiple rheological abnormalities are present in diabetes mellitus. Conclusions about erythrocyte rheology in particular will depend critically on the methodology used.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6948377

Citation

Oughton, J, and A J. Barnes. "Filterability and Vascular disease--I. Red Cell Filterability in Diabetes Mellitus: Its Relation to Other Methods of Measuring Deformability and to Blood Viscosity." Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum, vol. 156, 1981, pp. 151-4.
Oughton J, Barnes AJ. Filterability and vascular disease--I. Red cell filterability in diabetes mellitus: its relation to other methods of measuring deformability and to blood viscosity. Scand J Clin Lab Invest Suppl. 1981;156:151-4.
Oughton, J., & Barnes, A. J. (1981). Filterability and vascular disease--I. Red cell filterability in diabetes mellitus: its relation to other methods of measuring deformability and to blood viscosity. Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum, 156, pp. 151-4.
Oughton J, Barnes AJ. Filterability and Vascular disease--I. Red Cell Filterability in Diabetes Mellitus: Its Relation to Other Methods of Measuring Deformability and to Blood Viscosity. Scand J Clin Lab Invest Suppl. 1981;156:151-4. PubMed PMID: 6948377.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Filterability and vascular disease--I. Red cell filterability in diabetes mellitus: its relation to other methods of measuring deformability and to blood viscosity. AU - Oughton,J, AU - Barnes,A J, PY - 1981/1/1/pubmed PY - 1981/1/1/medline PY - 1981/1/1/entrez SP - 151 EP - 4 JF - Scandinavian journal of clinical and laboratory investigation. Supplementum JO - Scand. J. Clin. Lab. Invest. Suppl. VL - 156 N2 - Erythrocyte deformability, blood viscosity and other rheological variables were measured in 30 diabetics and 28 normal control subjects. Measurements of red cell rheology were made simultaneously by filtration of whole blood, centrifugation and viscometry of packed red cells. The diabetics showed a significant reduction of erythrocyte deformability measured by filtration, an increase in flexibility measured by centrifugation and values similar to normals for viscometry of packed red cells. Plasma viscosity but not whole blood viscosity (shear rates 23 and 230 s-1) was increased in the diabetics. Erythrocyte flexibility as measured by centrifugation was significantly related to blood viscosity and plasma fibrinogen and glucose in the diabetics, however, neither filtration nor viscometry of packed red cells correlated with other rheological variables. It seems likely that multiple rheological abnormalities are present in diabetes mellitus. Conclusions about erythrocyte rheology in particular will depend critically on the methodology used. SN - 0085-591X UR - https://www.unboundmedicine.com/medline/citation/6948377/Filterability_and_vascular_disease__I__Red_cell_filterability_in_diabetes_mellitus:_its_relation_to_other_methods_of_measuring_deformability_and_to_blood_viscosity_ L2 - http://www.diseaseinfosearch.org/result/2236 DB - PRIME DP - Unbound Medicine ER -