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Cross-resistance of cultured murine leukemia vincristine-resistant P388 cells to vinblastine, vindesine, and bis (N-ethylidene vindesine) disulfide, disulfate.
J Natl Cancer Inst. 1982 Jun; 68(6):1023-6.JNCI

Abstract

Cultured P388 leukemia cells derived from vincristine (VCR)-resistant cell populations developed in vivo in (C57BL X DBA/2)F1 mice (P388/VCR) were cross-resistant to vinblastine (VLB), vindesine (VDS), and bis(N-ethylidene vindesine)disulfide, disulfate (bis-VDS). Cross-resistance was a function of concentration and time of exposure. Cultured P388/VCR cells were more sensitive to 6.1x10-5Mbis- VDS than to 6.1x10-5MVDS or to 6.1x10-5MVLB. Cultured P388 cells derived from VCR-sensitive P388 leukemia passaged in vivo (P388/0)were significantly more sensitive to VDS and bis-VDS than to VLB. This degree of difference in sensitivity was also a function of concentration and time of exposure.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

6953266

Citation

Wilkoff, L J., and E A. Dulmadge. "Cross-resistance of Cultured Murine Leukemia Vincristine-resistant P388 Cells to Vinblastine, Vindesine, and Bis (N-ethylidene Vindesine) Disulfide, Disulfate." Journal of the National Cancer Institute, vol. 68, no. 6, 1982, pp. 1023-6.
Wilkoff LJ, Dulmadge EA. Cross-resistance of cultured murine leukemia vincristine-resistant P388 cells to vinblastine, vindesine, and bis (N-ethylidene vindesine) disulfide, disulfate. J Natl Cancer Inst. 1982;68(6):1023-6.
Wilkoff, L. J., & Dulmadge, E. A. (1982). Cross-resistance of cultured murine leukemia vincristine-resistant P388 cells to vinblastine, vindesine, and bis (N-ethylidene vindesine) disulfide, disulfate. Journal of the National Cancer Institute, 68(6), 1023-6.
Wilkoff LJ, Dulmadge EA. Cross-resistance of Cultured Murine Leukemia Vincristine-resistant P388 Cells to Vinblastine, Vindesine, and Bis (N-ethylidene Vindesine) Disulfide, Disulfate. J Natl Cancer Inst. 1982;68(6):1023-6. PubMed PMID: 6953266.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cross-resistance of cultured murine leukemia vincristine-resistant P388 cells to vinblastine, vindesine, and bis (N-ethylidene vindesine) disulfide, disulfate. AU - Wilkoff,L J, AU - Dulmadge,E A, PY - 1982/6/1/pubmed PY - 1982/6/1/medline PY - 1982/6/1/entrez SP - 1023 EP - 6 JF - Journal of the National Cancer Institute JO - J Natl Cancer Inst VL - 68 IS - 6 N2 - Cultured P388 leukemia cells derived from vincristine (VCR)-resistant cell populations developed in vivo in (C57BL X DBA/2)F1 mice (P388/VCR) were cross-resistant to vinblastine (VLB), vindesine (VDS), and bis(N-ethylidene vindesine)disulfide, disulfate (bis-VDS). Cross-resistance was a function of concentration and time of exposure. Cultured P388/VCR cells were more sensitive to 6.1x10-5Mbis- VDS than to 6.1x10-5MVDS or to 6.1x10-5MVLB. Cultured P388 cells derived from VCR-sensitive P388 leukemia passaged in vivo (P388/0)were significantly more sensitive to VDS and bis-VDS than to VLB. This degree of difference in sensitivity was also a function of concentration and time of exposure. SN - 0027-8874 UR - https://www.unboundmedicine.com/medline/citation/6953266/Cross_resistance_of_cultured_murine_leukemia_vincristine_resistant_P388_cells_to_vinblastine_vindesine_and_bis__N_ethylidene_vindesine__disulfide_disulfate_ DB - PRIME DP - Unbound Medicine ER -