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The enzymatic defects in porphyria cutanea tarda and variegate porphyria.

Abstract

Although enzymatic defects have been identified in porphyria cutanea tarda and variegate porphyria several important controversial points remain unresolved. Hepatic uroporphyrinogen decarboxylase activity is subnormal in all patients with porphyria cutanea tarda and is presumably responsible for the biochemical derangement which characterizes the disease. Several groups have found subnormal erythrocyte uroporphyrinogen decarboxylase activity as well and have demonstrated that the defect is inherited as an autosomal dominant trait. In other studies, erythrocyte enzyme activity has been normal and no evidence of an inherited factor has been identified. These two types of patients have been called "familial" and "sporadic" cases of porphyria cutanea tarda. Whether or not the hepatic enzyme defect is inherited in all cases remains to be determined. Two groups of investigators have identified two different enzymatic defects in variegate porphyria. One group has reported subnormal activity of heme synthase (ferrochelatase) to be the defect responsible for the disease and the other has reported subnormal activity of protoporphyrinogen oxidase to be the causative factor. Which of the two defects is responsible for the biochemical abnormalities in variegate porphyria remains to be resolved.

Authors

No affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

6962633

Citation

Kushner, J P.. "The Enzymatic Defects in Porphyria Cutanea Tarda and Variegate Porphyria." Acta Dermato-venereologica. Supplementum, vol. 100, 1982, pp. 51-6.
Kushner JP. The enzymatic defects in porphyria cutanea tarda and variegate porphyria. Acta Derm Venereol Suppl (Stockh). 1982;100:51-6.
Kushner, J. P. (1982). The enzymatic defects in porphyria cutanea tarda and variegate porphyria. Acta Dermato-venereologica. Supplementum, 100, pp. 51-6.
Kushner JP. The Enzymatic Defects in Porphyria Cutanea Tarda and Variegate Porphyria. Acta Derm Venereol Suppl (Stockh). 1982;100:51-6. PubMed PMID: 6962633.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The enzymatic defects in porphyria cutanea tarda and variegate porphyria. A1 - Kushner,J P, PY - 1982/1/1/pubmed PY - 1982/1/1/medline PY - 1982/1/1/entrez SP - 51 EP - 6 JF - Acta dermato-venereologica. Supplementum JO - Acta Derm Venereol Suppl (Stockh) VL - 100 N2 - Although enzymatic defects have been identified in porphyria cutanea tarda and variegate porphyria several important controversial points remain unresolved. Hepatic uroporphyrinogen decarboxylase activity is subnormal in all patients with porphyria cutanea tarda and is presumably responsible for the biochemical derangement which characterizes the disease. Several groups have found subnormal erythrocyte uroporphyrinogen decarboxylase activity as well and have demonstrated that the defect is inherited as an autosomal dominant trait. In other studies, erythrocyte enzyme activity has been normal and no evidence of an inherited factor has been identified. These two types of patients have been called "familial" and "sporadic" cases of porphyria cutanea tarda. Whether or not the hepatic enzyme defect is inherited in all cases remains to be determined. Two groups of investigators have identified two different enzymatic defects in variegate porphyria. One group has reported subnormal activity of heme synthase (ferrochelatase) to be the defect responsible for the disease and the other has reported subnormal activity of protoporphyrinogen oxidase to be the causative factor. Which of the two defects is responsible for the biochemical abnormalities in variegate porphyria remains to be resolved. SN - 0365-8341 UR - https://www.unboundmedicine.com/medline/citation/6962633/The_enzymatic_defects_in_porphyria_cutanea_tarda_and_variegate_porphyria_ L2 - http://www.diseaseinfosearch.org/result/7355 DB - PRIME DP - Unbound Medicine ER -