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Persistence of neutralizing antibody 30-35 years after immunization with 17D yellow fever vaccine.
Bull World Health Organ. 1981; 59(6):895-900.BW

Abstract

Previous studies on the duration of antibody following vaccination with 17D yellow fever (17D YF) virus vaccine have indicated that immunity persists for at least 17 years and suggest that the vaccine may provide lifelong immunity. We studied sera obtained from 149 veterans of the Second World War, 30 - 35 years after military service during which YF vaccination was required for defined groups. A significantly high proportion of "vaccinated" subjects was found to be seropositive to 17D YF virus. The highest proportion of seropositive "vaccinated" veterans (97%) was among navy and air corps personnel, while only 60% of "vaccinated" army personnel and 19% of "unvaccinated" personnel were seropositive. This study suggests that (i) antibody to 17D YF virus, as measured by the plaque-reduction neutralization test (PRNT), persists for 30 years or more following administration of a potent vaccine; (ii) army personnel often had not received potent vaccine, even though their service history indicated that they should have been vaccinated; (iii) some personnel were vaccinated, although their service did not include vaccination-designated areas; and (iv) 88% of veterans with persistent PRNT antibody to 17D YF virus also had mouse-protective antibody against French neurotropic YF virus.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

6978196

Citation

Poland, J D., et al. "Persistence of Neutralizing Antibody 30-35 Years After Immunization With 17D Yellow Fever Vaccine." Bulletin of the World Health Organization, vol. 59, no. 6, 1981, pp. 895-900.
Poland JD, Calisher CH, Monath TP, et al. Persistence of neutralizing antibody 30-35 years after immunization with 17D yellow fever vaccine. Bull World Health Organ. 1981;59(6):895-900.
Poland, J. D., Calisher, C. H., Monath, T. P., Downs, W. G., & Murphy, K. (1981). Persistence of neutralizing antibody 30-35 years after immunization with 17D yellow fever vaccine. Bulletin of the World Health Organization, 59(6), 895-900.
Poland JD, et al. Persistence of Neutralizing Antibody 30-35 Years After Immunization With 17D Yellow Fever Vaccine. Bull World Health Organ. 1981;59(6):895-900. PubMed PMID: 6978196.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Persistence of neutralizing antibody 30-35 years after immunization with 17D yellow fever vaccine. AU - Poland,J D, AU - Calisher,C H, AU - Monath,T P, AU - Downs,W G, AU - Murphy,K, PY - 1981/1/1/pubmed PY - 1981/1/1/medline PY - 1981/1/1/entrez SP - 895 EP - 900 JF - Bulletin of the World Health Organization JO - Bull World Health Organ VL - 59 IS - 6 N2 - Previous studies on the duration of antibody following vaccination with 17D yellow fever (17D YF) virus vaccine have indicated that immunity persists for at least 17 years and suggest that the vaccine may provide lifelong immunity. We studied sera obtained from 149 veterans of the Second World War, 30 - 35 years after military service during which YF vaccination was required for defined groups. A significantly high proportion of "vaccinated" subjects was found to be seropositive to 17D YF virus. The highest proportion of seropositive "vaccinated" veterans (97%) was among navy and air corps personnel, while only 60% of "vaccinated" army personnel and 19% of "unvaccinated" personnel were seropositive. This study suggests that (i) antibody to 17D YF virus, as measured by the plaque-reduction neutralization test (PRNT), persists for 30 years or more following administration of a potent vaccine; (ii) army personnel often had not received potent vaccine, even though their service history indicated that they should have been vaccinated; (iii) some personnel were vaccinated, although their service did not include vaccination-designated areas; and (iv) 88% of veterans with persistent PRNT antibody to 17D YF virus also had mouse-protective antibody against French neurotropic YF virus. SN - 0042-9686 UR - https://www.unboundmedicine.com/medline/citation/6978196/Persistence_of_neutralizing_antibody_30_35_years_after_immunization_with_17D_yellow_fever_vaccine_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/6978196/ DB - PRIME DP - Unbound Medicine ER -