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Lytic effect of cytotoxic lymphocytes on oral epithelial cells in Behçet's disease.
Br J Dermatol. 1982 Nov; 107(5):529-36.BJ

Abstract

The effect of blood lymphocytes on syngeneic oral epithelial cells was studied in twelve patients with Behçet's disease (BD) and twenty-one patients with recurrent aphthous ulcers (RAU). The control group consisted of twenty-five patients with non-aphthous skin disease and eight healthy individuals. Primary cell lines obtained from oral mucosa by suction blistering and subsequent enzymatic dissociation were used as target cells. Using a modified 51chromium release macro-assay, a significant lytic effect due to antibody-independent lymphocytotoxicity could be demonstrated in patients with BD, but no significant lysis of target cells was found in the RAU patients compared with the control group. These results provide further evidence that antibody-independent lymphocytotoxicity may play an important role in oral ulceration in BD.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6982060

Citation

Reimer, G, et al. "Lytic Effect of Cytotoxic Lymphocytes On Oral Epithelial Cells in Behçet's Disease." The British Journal of Dermatology, vol. 107, no. 5, 1982, pp. 529-36.
Reimer G, Steinkohl S, Djawari D, et al. Lytic effect of cytotoxic lymphocytes on oral epithelial cells in Behçet's disease. Br J Dermatol. 1982;107(5):529-36.
Reimer, G., Steinkohl, S., Djawari, D., & Hornstein, O. P. (1982). Lytic effect of cytotoxic lymphocytes on oral epithelial cells in Behçet's disease. The British Journal of Dermatology, 107(5), 529-36.
Reimer G, et al. Lytic Effect of Cytotoxic Lymphocytes On Oral Epithelial Cells in Behçet's Disease. Br J Dermatol. 1982;107(5):529-36. PubMed PMID: 6982060.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lytic effect of cytotoxic lymphocytes on oral epithelial cells in Behçet's disease. AU - Reimer,G, AU - Steinkohl,S, AU - Djawari,D, AU - Hornstein,O P, PY - 1982/11/1/pubmed PY - 1982/11/1/medline PY - 1982/11/1/entrez SP - 529 EP - 36 JF - The British journal of dermatology JO - Br. J. Dermatol. VL - 107 IS - 5 N2 - The effect of blood lymphocytes on syngeneic oral epithelial cells was studied in twelve patients with Behçet's disease (BD) and twenty-one patients with recurrent aphthous ulcers (RAU). The control group consisted of twenty-five patients with non-aphthous skin disease and eight healthy individuals. Primary cell lines obtained from oral mucosa by suction blistering and subsequent enzymatic dissociation were used as target cells. Using a modified 51chromium release macro-assay, a significant lytic effect due to antibody-independent lymphocytotoxicity could be demonstrated in patients with BD, but no significant lysis of target cells was found in the RAU patients compared with the control group. These results provide further evidence that antibody-independent lymphocytotoxicity may play an important role in oral ulceration in BD. SN - 0007-0963 UR - https://www.unboundmedicine.com/medline/citation/6982060/Lytic_effect_of_cytotoxic_lymphocytes_on_oral_epithelial_cells_in_Behçet's_disease_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0007-0963&date=1982&volume=107&issue=5&spage=529 DB - PRIME DP - Unbound Medicine ER -