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Effect of repeated carbon monoxide exposure to rats on cytochrome P-450 concentration and activities of monooxygenases in the liver.
Acta Biol Med Ger. 1982; 41(10):935-9.AB

Abstract

To determine the possible role of cytochrome P-450 in the adaptation response of an organism to chronic carbon monoxide exposure, rats received 4, 15 or 30 subcutaneous CO injections (7.2 mmol/kg body mass; maximal COHb concentration about 56%). The concentration of cytochrome P-450 is significantly reduced after 4 injections. This effect is no longer evident following 15 or 30 CO injections, which produced distinct increases of the total hemoglobin concentration. Ethylmorphine N-demethylation is distinctly inhibited after 4, 15 and 30 CO injections, whereas the initial inhibition of ethoxycoumarin O-deethylation disappears after 30 CO administrations. Ethoxyresorufin O-deethylation is only slightly influenced by CO.

Authors

Pankow D
No affiliation info available
Schiller F
No affiliation info available
Müller D
No affiliation info available

MeSH

7-Alkoxycoumarin O-DealkylaseAnimalsCarbon MonoxideCarboxyhemoglobinCytochrome P-450 Enzyme SystemEthylmorphine-N-DemethylaseLiverMaleOxygenasesRats

Pub Type(s)

Journal Article

Language

eng

PubMed ID

6984995

Citation

Pankow, D, et al. "Effect of Repeated Carbon Monoxide Exposure to Rats On Cytochrome P-450 Concentration and Activities of Monooxygenases in the Liver." Acta Biologica Et Medica Germanica, vol. 41, no. 10, 1982, pp. 935-9.
Pankow D, Schiller F, Müller D. Effect of repeated carbon monoxide exposure to rats on cytochrome P-450 concentration and activities of monooxygenases in the liver. Acta Biol Med Ger. 1982;41(10):935-9.
Pankow, D., Schiller, F., & Müller, D. (1982). Effect of repeated carbon monoxide exposure to rats on cytochrome P-450 concentration and activities of monooxygenases in the liver. Acta Biologica Et Medica Germanica, 41(10), 935-9.
Pankow D, Schiller F, Müller D. Effect of Repeated Carbon Monoxide Exposure to Rats On Cytochrome P-450 Concentration and Activities of Monooxygenases in the Liver. Acta Biol Med Ger. 1982;41(10):935-9. PubMed PMID: 6984995.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of repeated carbon monoxide exposure to rats on cytochrome P-450 concentration and activities of monooxygenases in the liver. AU - Pankow,D, AU - Schiller,F, AU - Müller,D, PY - 1982/1/1/pubmed PY - 1982/1/1/medline PY - 1982/1/1/entrez SP - 935 EP - 9 JF - Acta biologica et medica Germanica JO - Acta Biol Med Ger VL - 41 IS - 10 N2 - To determine the possible role of cytochrome P-450 in the adaptation response of an organism to chronic carbon monoxide exposure, rats received 4, 15 or 30 subcutaneous CO injections (7.2 mmol/kg body mass; maximal COHb concentration about 56%). The concentration of cytochrome P-450 is significantly reduced after 4 injections. This effect is no longer evident following 15 or 30 CO injections, which produced distinct increases of the total hemoglobin concentration. Ethylmorphine N-demethylation is distinctly inhibited after 4, 15 and 30 CO injections, whereas the initial inhibition of ethoxycoumarin O-deethylation disappears after 30 CO administrations. Ethoxyresorufin O-deethylation is only slightly influenced by CO. SN - 0001-5318 UR - https://www.unboundmedicine.com/medline/citation/6984995/Effect_of_repeated_carbon_monoxide_exposure_to_rats_on_cytochrome_P_450_concentration_and_activities_of_monooxygenases_in_the_liver_ DB - PRIME DP - Unbound Medicine ER -