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Increased incidence of retinopathy in diabetics with elevated blood pressure. A six-year follow-up study in Pima Indians.
N Engl J Med 1980; 302(12):645-50NEJM

Abstract

The incidence of retinopathy was assessed in 188 diabetic and 284 nondiabetic Pima Indian adults six years after an initial examination had shown each to be free of retinopathy. Exminations included direct ophthalmoscopy through dilated pupils. The incidence of retinal lesions was strongly related to the presence of diabetes and, among the diabetic subjects, to insulin treatment, disease duration, plasma glucose concentration, and presence of other complications such as proteinuria, loss of deep tendon reflexes, and increased vibration-sensation threshold. In diabetic subjects not taking insulin, the incidence of exudates in those with systolic blood pressures of at least 145 mm Hg was more than twice that of those with pressures of less than 125 mm Hg. This association persisted when assessed within categories of subjects stratified according to 13 potentially confounding variables, suggesting that control of blood pressure may reduce the incidence of retinal exudates in diabetics not treated with insulin.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

6986550

Citation

Knowler, W C., et al. "Increased Incidence of Retinopathy in Diabetics With Elevated Blood Pressure. a Six-year Follow-up Study in Pima Indians." The New England Journal of Medicine, vol. 302, no. 12, 1980, pp. 645-50.
Knowler WC, Bennett PH, Ballintine EJ. Increased incidence of retinopathy in diabetics with elevated blood pressure. A six-year follow-up study in Pima Indians. N Engl J Med. 1980;302(12):645-50.
Knowler, W. C., Bennett, P. H., & Ballintine, E. J. (1980). Increased incidence of retinopathy in diabetics with elevated blood pressure. A six-year follow-up study in Pima Indians. The New England Journal of Medicine, 302(12), pp. 645-50.
Knowler WC, Bennett PH, Ballintine EJ. Increased Incidence of Retinopathy in Diabetics With Elevated Blood Pressure. a Six-year Follow-up Study in Pima Indians. N Engl J Med. 1980 Mar 20;302(12):645-50. PubMed PMID: 6986550.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased incidence of retinopathy in diabetics with elevated blood pressure. A six-year follow-up study in Pima Indians. AU - Knowler,W C, AU - Bennett,P H, AU - Ballintine,E J, PY - 1980/3/20/pubmed PY - 1980/3/20/medline PY - 1980/3/20/entrez SP - 645 EP - 50 JF - The New England journal of medicine JO - N. Engl. J. Med. VL - 302 IS - 12 N2 - The incidence of retinopathy was assessed in 188 diabetic and 284 nondiabetic Pima Indian adults six years after an initial examination had shown each to be free of retinopathy. Exminations included direct ophthalmoscopy through dilated pupils. The incidence of retinal lesions was strongly related to the presence of diabetes and, among the diabetic subjects, to insulin treatment, disease duration, plasma glucose concentration, and presence of other complications such as proteinuria, loss of deep tendon reflexes, and increased vibration-sensation threshold. In diabetic subjects not taking insulin, the incidence of exudates in those with systolic blood pressures of at least 145 mm Hg was more than twice that of those with pressures of less than 125 mm Hg. This association persisted when assessed within categories of subjects stratified according to 13 potentially confounding variables, suggesting that control of blood pressure may reduce the incidence of retinal exudates in diabetics not treated with insulin. SN - 0028-4793 UR - https://www.unboundmedicine.com/medline/citation/6986550/full_citation L2 - http://www.nejm.org/doi/full/10.1056/NEJM198003203021201?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -