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Increased incidence of retinopathy in diabetics with elevated blood pressure. A six-year follow-up study in Pima Indians.

Abstract

The incidence of retinopathy was assessed in 188 diabetic and 284 nondiabetic Pima Indian adults six years after an initial examination had shown each to be free of retinopathy. Exminations included direct ophthalmoscopy through dilated pupils. The incidence of retinal lesions was strongly related to the presence of diabetes and, among the diabetic subjects, to insulin treatment, disease duration, plasma glucose concentration, and presence of other complications such as proteinuria, loss of deep tendon reflexes, and increased vibration-sensation threshold. In diabetic subjects not taking insulin, the incidence of exudates in those with systolic blood pressures of at least 145 mm Hg was more than twice that of those with pressures of less than 125 mm Hg. This association persisted when assessed within categories of subjects stratified according to 13 potentially confounding variables, suggesting that control of blood pressure may reduce the incidence of retinal exudates in diabetics not treated with insulin.

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  • Publisher Full Text
  • Authors

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    Source

    The New England journal of medicine 302:12 1980 Mar 20 pg 645-50

    MeSH

    Adult
    Aged
    Arizona
    Blood Glucose
    Diabetes Complications
    Diabetes Mellitus
    Diabetic Retinopathy
    Female
    Follow-Up Studies
    Humans
    Hypertension
    Indians, North American
    Insulin
    Male
    Middle Aged
    Reflex, Stretch
    Sensory Thresholds
    Time Factors
    Vibration

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    6986550

    Citation

    Knowler, W C., et al. "Increased Incidence of Retinopathy in Diabetics With Elevated Blood Pressure. a Six-year Follow-up Study in Pima Indians." The New England Journal of Medicine, vol. 302, no. 12, 1980, pp. 645-50.
    Knowler WC, Bennett PH, Ballintine EJ. Increased incidence of retinopathy in diabetics with elevated blood pressure. A six-year follow-up study in Pima Indians. N Engl J Med. 1980;302(12):645-50.
    Knowler, W. C., Bennett, P. H., & Ballintine, E. J. (1980). Increased incidence of retinopathy in diabetics with elevated blood pressure. A six-year follow-up study in Pima Indians. The New England Journal of Medicine, 302(12), pp. 645-50.
    Knowler WC, Bennett PH, Ballintine EJ. Increased Incidence of Retinopathy in Diabetics With Elevated Blood Pressure. a Six-year Follow-up Study in Pima Indians. N Engl J Med. 1980 Mar 20;302(12):645-50. PubMed PMID: 6986550.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Increased incidence of retinopathy in diabetics with elevated blood pressure. A six-year follow-up study in Pima Indians. AU - Knowler,W C, AU - Bennett,P H, AU - Ballintine,E J, PY - 1980/3/20/pubmed PY - 1980/3/20/medline PY - 1980/3/20/entrez SP - 645 EP - 50 JF - The New England journal of medicine JO - N. Engl. J. Med. VL - 302 IS - 12 N2 - The incidence of retinopathy was assessed in 188 diabetic and 284 nondiabetic Pima Indian adults six years after an initial examination had shown each to be free of retinopathy. Exminations included direct ophthalmoscopy through dilated pupils. The incidence of retinal lesions was strongly related to the presence of diabetes and, among the diabetic subjects, to insulin treatment, disease duration, plasma glucose concentration, and presence of other complications such as proteinuria, loss of deep tendon reflexes, and increased vibration-sensation threshold. In diabetic subjects not taking insulin, the incidence of exudates in those with systolic blood pressures of at least 145 mm Hg was more than twice that of those with pressures of less than 125 mm Hg. This association persisted when assessed within categories of subjects stratified according to 13 potentially confounding variables, suggesting that control of blood pressure may reduce the incidence of retinal exudates in diabetics not treated with insulin. SN - 0028-4793 UR - https://www.unboundmedicine.com/medline/citation/6986550/full_citation L2 - http://www.nejm.org/doi/full/10.1056/NEJM198003203021201?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -