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Reduction of serum gastrin response to insulin hypoglycemia by selective vagotomy with pyloroplasty in duodenal ulcer patients.
Surgery. 1980 Mar; 87(3):294-9.S

Abstract

We have previously demonstrated that insulin hypoglycemia releases antral gastrin by a pH sensitive mechanism in duodenal ulcer (DU) patients. The effect of vagotomy per se on the hypoglycemic release of gastrin therefore might be obscured by alterations in antral pH. In the present study on 11 DU patients, the gastric acid response to intravenously administered insulin (0.2 units/kg-1) was determined before and after selective vagotomy with pyloroplasty (SV + PP). In another preoperative and postoperative test on each patient, the serum gastrin test, the serum gastrin response (radioimmunoassay) to insulin was determined during gastric perfusion with citrate-phosphate buffer pH 7.0. By adjusting the perfusion rate, the intragastric pH was maintained at 5.0 or higher. SV + PP abolished the acid response to insulin in four and reduced the response by 80% to 95% in another six patients. Gastric buffer perfusion or SV + PP did not alter the basal serum gastrin level. The increase of serum gastrin level after insulin was significantly (P less than 0.01) reduced by SV + PP. Before operation the integrated serum gastrin response to insulin was significant (P less than 0.01). SV + PP reduced the response to one-third. The effect of SV + PP on the hypoglycemic release of gastrin varied among the patients but no relationship was found to the effect on the acid response, nor to the variations of the volume or pH of the perfusate (pH range, 5.0 to 7.5). It is concluded that insulin hypoglycemia releases antral gastrin by a vagal and probably also by a nonvagal mechanism and that both mechanisms are pH sensitive.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

6987766

Citation

Emås, S, et al. "Reduction of Serum Gastrin Response to Insulin Hypoglycemia By Selective Vagotomy With Pyloroplasty in Duodenal Ulcer Patients." Surgery, vol. 87, no. 3, 1980, pp. 294-9.
Emås S, Svensson SO, Lilja B, et al. Reduction of serum gastrin response to insulin hypoglycemia by selective vagotomy with pyloroplasty in duodenal ulcer patients. Surgery. 1980;87(3):294-9.
Emås, S., Svensson, S. O., Lilja, B., & Kaess, H. (1980). Reduction of serum gastrin response to insulin hypoglycemia by selective vagotomy with pyloroplasty in duodenal ulcer patients. Surgery, 87(3), 294-9.
Emås S, et al. Reduction of Serum Gastrin Response to Insulin Hypoglycemia By Selective Vagotomy With Pyloroplasty in Duodenal Ulcer Patients. Surgery. 1980;87(3):294-9. PubMed PMID: 6987766.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reduction of serum gastrin response to insulin hypoglycemia by selective vagotomy with pyloroplasty in duodenal ulcer patients. AU - Emås,S, AU - Svensson,S O, AU - Lilja,B, AU - Kaess,H, PY - 1980/3/1/pubmed PY - 1980/3/1/medline PY - 1980/3/1/entrez SP - 294 EP - 9 JF - Surgery JO - Surgery VL - 87 IS - 3 N2 - We have previously demonstrated that insulin hypoglycemia releases antral gastrin by a pH sensitive mechanism in duodenal ulcer (DU) patients. The effect of vagotomy per se on the hypoglycemic release of gastrin therefore might be obscured by alterations in antral pH. In the present study on 11 DU patients, the gastric acid response to intravenously administered insulin (0.2 units/kg-1) was determined before and after selective vagotomy with pyloroplasty (SV + PP). In another preoperative and postoperative test on each patient, the serum gastrin test, the serum gastrin response (radioimmunoassay) to insulin was determined during gastric perfusion with citrate-phosphate buffer pH 7.0. By adjusting the perfusion rate, the intragastric pH was maintained at 5.0 or higher. SV + PP abolished the acid response to insulin in four and reduced the response by 80% to 95% in another six patients. Gastric buffer perfusion or SV + PP did not alter the basal serum gastrin level. The increase of serum gastrin level after insulin was significantly (P less than 0.01) reduced by SV + PP. Before operation the integrated serum gastrin response to insulin was significant (P less than 0.01). SV + PP reduced the response to one-third. The effect of SV + PP on the hypoglycemic release of gastrin varied among the patients but no relationship was found to the effect on the acid response, nor to the variations of the volume or pH of the perfusate (pH range, 5.0 to 7.5). It is concluded that insulin hypoglycemia releases antral gastrin by a vagal and probably also by a nonvagal mechanism and that both mechanisms are pH sensitive. SN - 0039-6060 UR - https://www.unboundmedicine.com/medline/citation/6987766/Reduction_of_serum_gastrin_response_to_insulin_hypoglycemia_by_selective_vagotomy_with_pyloroplasty_in_duodenal_ulcer_patients_ L2 - http://www.diseaseinfosearch.org/result/9680 DB - PRIME DP - Unbound Medicine ER -