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Free-radical reaction in biological systems.
Ann R Coll Surg Engl 1980; 62(3):188-94AR

Abstract

Free radicals are a highly reactive chemical species which differ from all other species in possessing an unpaired electron. Although free-radical activity in living systems is energetically improbable, recent work suggests that a number of important biological processes depend on it. In contrast to enzymic metabolism these free-radical processes tend to be non-cyclic, irreversible, non-homoeostatic, and energetically wasteful. For the organism as a whole they may nevertheless have considerable survival value. Free radicals are too short-lived to be demonstrable in tissues; but methodological advances are leading to the detection and measurement of characteristic free-radical reaction products. The findings suggest that free-radical activity is not only a potential cause but also a common, perhaps invariable, consequence of cell damage. It is possible that some of the secondary products of free-radical reactions may help to regulate the body's local and systemic response to injury.

Authors

No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

6994571

Citation

Dormandy, T L.. "Free-radical Reaction in Biological Systems." Annals of the Royal College of Surgeons of England, vol. 62, no. 3, 1980, pp. 188-94.
Dormandy TL. Free-radical reaction in biological systems. Ann R Coll Surg Engl. 1980;62(3):188-94.
Dormandy, T. L. (1980). Free-radical reaction in biological systems. Annals of the Royal College of Surgeons of England, 62(3), pp. 188-94.
Dormandy TL. Free-radical Reaction in Biological Systems. Ann R Coll Surg Engl. 1980;62(3):188-94. PubMed PMID: 6994571.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Free-radical reaction in biological systems. A1 - Dormandy,T L, PY - 1980/5/1/pubmed PY - 1980/5/1/medline PY - 1980/5/1/entrez SP - 188 EP - 94 JF - Annals of the Royal College of Surgeons of England JO - Ann R Coll Surg Engl VL - 62 IS - 3 N2 - Free radicals are a highly reactive chemical species which differ from all other species in possessing an unpaired electron. Although free-radical activity in living systems is energetically improbable, recent work suggests that a number of important biological processes depend on it. In contrast to enzymic metabolism these free-radical processes tend to be non-cyclic, irreversible, non-homoeostatic, and energetically wasteful. For the organism as a whole they may nevertheless have considerable survival value. Free radicals are too short-lived to be demonstrable in tissues; but methodological advances are leading to the detection and measurement of characteristic free-radical reaction products. The findings suggest that free-radical activity is not only a potential cause but also a common, perhaps invariable, consequence of cell damage. It is possible that some of the secondary products of free-radical reactions may help to regulate the body's local and systemic response to injury. SN - 0035-8843 UR - https://www.unboundmedicine.com/medline/citation/6994571/Free_radical_reaction_in_biological_systems_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/6994571/ DB - PRIME DP - Unbound Medicine ER -