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Investigation of insulin sensitivity in early diabetes. II. Insulin resistance in asymptomatic diabetics.
Endokrinologie. 1980 Jul; 76(1):103-11.E

Abstract

Thirty-eight non-obese and seven obese subjects were classified by a 2-hour glucose infusion test as having a normal carbohydrate tolerance. Sixteen non-obese ad ten obese patients showed a pathological carbohydrate tolerance (asymptomatic diabetes). For the characterization of insulin sensitivity a 1-hour priming dose-constant infusion technique consisting of two 30-minute-periods was applied in all subjects. A decrease of glycemia during this insulin infusion of less than 22.5 per cent has been accepted as a criterion of insulin insensitivity. Sixty-three per cent of non-obese and seventy-eight per cent of obese asymptomatic diabetics exhibited a reduced responsiveness to insulin. There ws an inverse relationship between the per cent decrease of plasma glucose concentration and the insulin secretion pattern revealed by the glucose infusion test. The results suggest that insulin resistance is a characteristic feature of obese and non-obese asymptomatic diabetics.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7002536

Citation

Schulz, B, et al. "Investigation of Insulin Sensitivity in Early Diabetes. II. Insulin Resistance in Asymptomatic Diabetics." Endokrinologie, vol. 76, no. 1, 1980, pp. 103-11.
Schulz B, Ratzmann KP, Witt S, et al. Investigation of insulin sensitivity in early diabetes. II. Insulin resistance in asymptomatic diabetics. Endokrinologie. 1980;76(1):103-11.
Schulz, B., Ratzmann, K. P., Witt, S., Anders, M., & Ehrlich, M. (1980). Investigation of insulin sensitivity in early diabetes. II. Insulin resistance in asymptomatic diabetics. Endokrinologie, 76(1), 103-11.
Schulz B, et al. Investigation of Insulin Sensitivity in Early Diabetes. II. Insulin Resistance in Asymptomatic Diabetics. Endokrinologie. 1980;76(1):103-11. PubMed PMID: 7002536.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Investigation of insulin sensitivity in early diabetes. II. Insulin resistance in asymptomatic diabetics. AU - Schulz,B, AU - Ratzmann,K P, AU - Witt,S, AU - Anders,M, AU - Ehrlich,M, PY - 1980/7/1/pubmed PY - 1980/7/1/medline PY - 1980/7/1/entrez SP - 103 EP - 11 JF - Endokrinologie JO - Endokrinologie VL - 76 IS - 1 N2 - Thirty-eight non-obese and seven obese subjects were classified by a 2-hour glucose infusion test as having a normal carbohydrate tolerance. Sixteen non-obese ad ten obese patients showed a pathological carbohydrate tolerance (asymptomatic diabetes). For the characterization of insulin sensitivity a 1-hour priming dose-constant infusion technique consisting of two 30-minute-periods was applied in all subjects. A decrease of glycemia during this insulin infusion of less than 22.5 per cent has been accepted as a criterion of insulin insensitivity. Sixty-three per cent of non-obese and seventy-eight per cent of obese asymptomatic diabetics exhibited a reduced responsiveness to insulin. There ws an inverse relationship between the per cent decrease of plasma glucose concentration and the insulin secretion pattern revealed by the glucose infusion test. The results suggest that insulin resistance is a characteristic feature of obese and non-obese asymptomatic diabetics. SN - 0013-7251 UR - https://www.unboundmedicine.com/medline/citation/7002536/Investigation_of_insulin_sensitivity_in_early_diabetes__II__Insulin_resistance_in_asymptomatic_diabetics_ L2 - http://www.diseaseinfosearch.org/result/2236 DB - PRIME DP - Unbound Medicine ER -