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Inhibitory effect of coffee on lower esophageal sphincter pressure.

Abstract

We examined the effect of 150 ml of caffeinated instant coffee at two pHs, 4.5 and 7.0, on lower esophageal sphincter pressure in 20 normal volunteers and 16 patients with reflux esophagitis. When ingested alone coffee at pH 4.5 and 7.0 caused a decrease in basal sphincter pressure in normal volunteers from 19.4 +/- 1.5 to 13.7 +/- 1.0 mmHg (P ¿ 0.01) and from 18.7 +/- 1.5 to 16.0 +/- 0.8 mmHg (P < 0.05) respectively. When coffee at pH 4.5 was drunk with a mixed nutrient test meal, the resting sphincter pressure in normal subjects fell after 30-60 min with the nadir, 11.2 +/- 1.0 mmHg, being recorded at 60 min (P < 0.01). Coffee at pH 7.0 with the test meal resulted in a fall in pressure to 14.3 +/- 1.5 mmHg (P < 0.02) at 60 min. In patients with reflux esophagitis, coffee at pH 4.5 lowered lower esophageal sphincter pressure from 9.1 +/- 1.0 to 5.5 +/- 0.6 mmHg (P < 0.005); coffee at pH 7.0 decreased lower esophageal sphincter pressure from 8.5 +/- 1.1 to 6.9 +/- 0.7 mmHg (P < 0.05). In these patients, mean basal pressure, 9.2 +/- 0.8 mmHg, decreased to 5.2 +/- 0.7 mmHg (P < 0.001) 45 min after drinking coffee at pH 4.5 with the test meal. Coffee at the neutral pH caused a fall in pressure from 8.8 +/- 1.1 to 6.5 +/- 0.7 mmHg at 60 min after the test meal. Thus, coffee at either pH 4.5 or 7.0 caused a decrease in fasting and postcibal lower esophageal sphincter pressure in normal volunteers and patients with reflux esophagitis. The magnitude and the duration of the effect were greater after coffee at the lower pH. These data support the clinical belief that coffee may cause or aggravate heartburn by decreasing lower esophageal sphincter pressure.

Authors

, , , ,

Source

Gastroenterology 79:6 1980 Dec pg 1262-6

MeSH

Adult
Caffeine
Clinical Trials as Topic
Coffee
Depression, Chemical
Esophagitis, Peptic
Esophagogastric Junction
Female
Gastrointestinal Motility
Heartburn
Humans
Male
Peristalsis
Pressure

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

7002705

Citation

Thomas, F B., et al. "Inhibitory Effect of Coffee On Lower Esophageal Sphincter Pressure." Gastroenterology, vol. 79, no. 6, 1980, pp. 1262-6.
Thomas FB, Steinbaugh JT, Fromkes JJ, et al. Inhibitory effect of coffee on lower esophageal sphincter pressure. Gastroenterology. 1980;79(6):1262-6.
Thomas, F. B., Steinbaugh, J. T., Fromkes, J. J., Mekhjian, H. S., & Caldwell, J. H. (1980). Inhibitory effect of coffee on lower esophageal sphincter pressure. Gastroenterology, 79(6), pp. 1262-6.
Thomas FB, et al. Inhibitory Effect of Coffee On Lower Esophageal Sphincter Pressure. Gastroenterology. 1980;79(6):1262-6. PubMed PMID: 7002705.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhibitory effect of coffee on lower esophageal sphincter pressure. AU - Thomas,F B, AU - Steinbaugh,J T, AU - Fromkes,J J, AU - Mekhjian,H S, AU - Caldwell,J H, PY - 1980/12/1/pubmed PY - 1980/12/1/medline PY - 1980/12/1/entrez SP - 1262 EP - 6 JF - Gastroenterology JO - Gastroenterology VL - 79 IS - 6 N2 - We examined the effect of 150 ml of caffeinated instant coffee at two pHs, 4.5 and 7.0, on lower esophageal sphincter pressure in 20 normal volunteers and 16 patients with reflux esophagitis. When ingested alone coffee at pH 4.5 and 7.0 caused a decrease in basal sphincter pressure in normal volunteers from 19.4 +/- 1.5 to 13.7 +/- 1.0 mmHg (P ¿ 0.01) and from 18.7 +/- 1.5 to 16.0 +/- 0.8 mmHg (P < 0.05) respectively. When coffee at pH 4.5 was drunk with a mixed nutrient test meal, the resting sphincter pressure in normal subjects fell after 30-60 min with the nadir, 11.2 +/- 1.0 mmHg, being recorded at 60 min (P < 0.01). Coffee at pH 7.0 with the test meal resulted in a fall in pressure to 14.3 +/- 1.5 mmHg (P < 0.02) at 60 min. In patients with reflux esophagitis, coffee at pH 4.5 lowered lower esophageal sphincter pressure from 9.1 +/- 1.0 to 5.5 +/- 0.6 mmHg (P < 0.005); coffee at pH 7.0 decreased lower esophageal sphincter pressure from 8.5 +/- 1.1 to 6.9 +/- 0.7 mmHg (P < 0.05). In these patients, mean basal pressure, 9.2 +/- 0.8 mmHg, decreased to 5.2 +/- 0.7 mmHg (P < 0.001) 45 min after drinking coffee at pH 4.5 with the test meal. Coffee at the neutral pH caused a fall in pressure from 8.8 +/- 1.1 to 6.5 +/- 0.7 mmHg at 60 min after the test meal. Thus, coffee at either pH 4.5 or 7.0 caused a decrease in fasting and postcibal lower esophageal sphincter pressure in normal volunteers and patients with reflux esophagitis. The magnitude and the duration of the effect were greater after coffee at the lower pH. These data support the clinical belief that coffee may cause or aggravate heartburn by decreasing lower esophageal sphincter pressure. SN - 0016-5085 UR - https://www.unboundmedicine.com/medline/citation/7002705/full_citation L2 - https://medlineplus.gov/caffeine.html DB - PRIME DP - Unbound Medicine ER -