Tags

Type your tag names separated by a space and hit enter

[Treatment of arterial hypertension in the elderly with an alpha-blocker: nicergoline (author's transl)].

Abstract

The tolerance and anti-hypertensive activity of nicergoline, an alpha-adrenoceptor blocking agent, were studied in 28 hypertensive subjects older than 65 years (mean age: 84 years). The trial was conducted double-blind: 14 subjects were given nicergoline 30 mg/day divided into 6 doses ("lyocs"), and 14 subjects received a placebo identical in appearance with the drug. A mean decrease of 34 mm Hg in systolic arterial pressure (p < 0.001) and of 16 mm Hg in diastolic arterial pressure (p < 0.001) was observed in subjects under nicergoline. The corresponding changes in blood pressure (-12 and -7.9 mm Hg respectively) in subjects under placebo were not significant. No side-effect requiring discontinuation of treatment was encountered. The remarkable effectiveness and tolerance of nicergoline make it a highly suitable agent for the treatment of hypertension in elderly people.

Authors

, , ,

Source

La Nouvelle presse medicale 9:48 1980 Dec 20 pg 3685-8

MeSH

Aged
Clinical Trials as Topic
Double-Blind Method
Ergolines
Female
Humans
Hypertension
Male
Nicergoline

Pub Type(s)

Clinical Trial
English Abstract
Journal Article
Randomized Controlled Trial

Language

fre

PubMed ID

7005872

Citation

Forette, F, et al. "[Treatment of Arterial Hypertension in the Elderly With an Alpha-blocker: Nicergoline (author's Transl)]." La Nouvelle Presse Medicale, vol. 9, no. 48, 1980, pp. 3685-8.
Forette F, Varin D, Henry JF, et al. [Treatment of arterial hypertension in the elderly with an alpha-blocker: nicergoline (author's transl)]. Nouv Presse Med. 1980;9(48):3685-8.
Forette, F., Varin, D., Henry, J. F., & Hervy, M. P. (1980). [Treatment of arterial hypertension in the elderly with an alpha-blocker: nicergoline (author's transl)]. La Nouvelle Presse Medicale, 9(48), pp. 3685-8.
Forette F, et al. [Treatment of Arterial Hypertension in the Elderly With an Alpha-blocker: Nicergoline (author's Transl)]. Nouv Presse Med. 1980 Dec 20;9(48):3685-8. PubMed PMID: 7005872.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Treatment of arterial hypertension in the elderly with an alpha-blocker: nicergoline (author's transl)]. AU - Forette,F, AU - Varin,D, AU - Henry,J F, AU - Hervy,M P, PY - 1980/12/20/pubmed PY - 1980/12/20/medline PY - 1980/12/20/entrez SP - 3685 EP - 8 JF - La Nouvelle presse medicale JO - Nouv Presse Med VL - 9 IS - 48 N2 - The tolerance and anti-hypertensive activity of nicergoline, an alpha-adrenoceptor blocking agent, were studied in 28 hypertensive subjects older than 65 years (mean age: 84 years). The trial was conducted double-blind: 14 subjects were given nicergoline 30 mg/day divided into 6 doses ("lyocs"), and 14 subjects received a placebo identical in appearance with the drug. A mean decrease of 34 mm Hg in systolic arterial pressure (p < 0.001) and of 16 mm Hg in diastolic arterial pressure (p < 0.001) was observed in subjects under nicergoline. The corresponding changes in blood pressure (-12 and -7.9 mm Hg respectively) in subjects under placebo were not significant. No side-effect requiring discontinuation of treatment was encountered. The remarkable effectiveness and tolerance of nicergoline make it a highly suitable agent for the treatment of hypertension in elderly people. SN - 0301-1518 UR - https://www.unboundmedicine.com/medline/citation/7005872/[Treatment_of_arterial_hypertension_in_the_elderly_with_an_alpha_blocker:_nicergoline__author's_transl_]_ L2 - https://medlineplus.gov/highbloodpressure.html DB - PRIME DP - Unbound Medicine ER -