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[Treatment of arterial hypertension in the elderly with an alpha-blocker: nicergoline (author's transl)].
Nouv Presse Med 1980; 9(48):3685-8NP

Abstract

The tolerance and anti-hypertensive activity of nicergoline, an alpha-adrenoceptor blocking agent, were studied in 28 hypertensive subjects older than 65 years (mean age: 84 years). The trial was conducted double-blind: 14 subjects were given nicergoline 30 mg/day divided into 6 doses ("lyocs"), and 14 subjects received a placebo identical in appearance with the drug. A mean decrease of 34 mm Hg in systolic arterial pressure (p < 0.001) and of 16 mm Hg in diastolic arterial pressure (p < 0.001) was observed in subjects under nicergoline. The corresponding changes in blood pressure (-12 and -7.9 mm Hg respectively) in subjects under placebo were not significant. No side-effect requiring discontinuation of treatment was encountered. The remarkable effectiveness and tolerance of nicergoline make it a highly suitable agent for the treatment of hypertension in elderly people.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
English Abstract
Journal Article
Randomized Controlled Trial

Language

fre

PubMed ID

7005872

Citation

Forette, F, et al. "[Treatment of Arterial Hypertension in the Elderly With an Alpha-blocker: Nicergoline (author's Transl)]." La Nouvelle Presse Medicale, vol. 9, no. 48, 1980, pp. 3685-8.
Forette F, Varin D, Henry JF, et al. [Treatment of arterial hypertension in the elderly with an alpha-blocker: nicergoline (author's transl)]. Nouv Presse Med. 1980;9(48):3685-8.
Forette, F., Varin, D., Henry, J. F., & Hervy, M. P. (1980). [Treatment of arterial hypertension in the elderly with an alpha-blocker: nicergoline (author's transl)]. La Nouvelle Presse Medicale, 9(48), pp. 3685-8.
Forette F, et al. [Treatment of Arterial Hypertension in the Elderly With an Alpha-blocker: Nicergoline (author's Transl)]. Nouv Presse Med. 1980 Dec 20;9(48):3685-8. PubMed PMID: 7005872.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Treatment of arterial hypertension in the elderly with an alpha-blocker: nicergoline (author's transl)]. AU - Forette,F, AU - Varin,D, AU - Henry,J F, AU - Hervy,M P, PY - 1980/12/20/pubmed PY - 1980/12/20/medline PY - 1980/12/20/entrez SP - 3685 EP - 8 JF - La Nouvelle presse medicale JO - Nouv Presse Med VL - 9 IS - 48 N2 - The tolerance and anti-hypertensive activity of nicergoline, an alpha-adrenoceptor blocking agent, were studied in 28 hypertensive subjects older than 65 years (mean age: 84 years). The trial was conducted double-blind: 14 subjects were given nicergoline 30 mg/day divided into 6 doses ("lyocs"), and 14 subjects received a placebo identical in appearance with the drug. A mean decrease of 34 mm Hg in systolic arterial pressure (p < 0.001) and of 16 mm Hg in diastolic arterial pressure (p < 0.001) was observed in subjects under nicergoline. The corresponding changes in blood pressure (-12 and -7.9 mm Hg respectively) in subjects under placebo were not significant. No side-effect requiring discontinuation of treatment was encountered. The remarkable effectiveness and tolerance of nicergoline make it a highly suitable agent for the treatment of hypertension in elderly people. SN - 0301-1518 UR - https://www.unboundmedicine.com/medline/citation/7005872/[Treatment_of_arterial_hypertension_in_the_elderly_with_an_alpha_blocker:_nicergoline__author's_transl_]_ L2 - https://medlineplus.gov/highbloodpressure.html DB - PRIME DP - Unbound Medicine ER -