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Lead-erythrocyte protoporphyrin correlation in blood of exposed workers.
Health Lab Sci. 1978 Jul; 15(3):144-9.HL

Abstract

A systematic survey of blood samples from 174 industrial workers occupationally exposed to lead fumes and lead dust, revealed some poor correlations between the lead (Pb) level and the free erythrocyte protoporphyrin (FEP) level. In addition to those workers who had an expected correlation (normal Pb-normal FEP or elevated Pb-elevated FEP) there were two groups with atypical correlations. In one group a normal Pb level was associated with an elevated FEP level and in the other group an elevated Pb level was associated with a normal FEP level. This shows that neither the Pb nor the FEP test can substitute for the other. Since the individual FEP response to Pb absorption is unpredictable, both tests should be carried out routinely. This would make it possible to determine simultaneously the degree of absorption (Pb level) and the degree of intoxication (FEP level) and would improve significantly the assessment of undue lead absorption of occupationally exposed workers. If, however, only one of these tests is used for screening the other test should always be carried out as a confirmatory test when the screening detects an elevated Pb or FEP level.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

701012

Citation

Peter, F, and R G. Reynolds. "Lead-erythrocyte Protoporphyrin Correlation in Blood of Exposed Workers." Health Laboratory Science, vol. 15, no. 3, 1978, pp. 144-9.
Peter F, Reynolds RG. Lead-erythrocyte protoporphyrin correlation in blood of exposed workers. Health Lab Sci. 1978;15(3):144-9.
Peter, F., & Reynolds, R. G. (1978). Lead-erythrocyte protoporphyrin correlation in blood of exposed workers. Health Laboratory Science, 15(3), 144-9.
Peter F, Reynolds RG. Lead-erythrocyte Protoporphyrin Correlation in Blood of Exposed Workers. Health Lab Sci. 1978;15(3):144-9. PubMed PMID: 701012.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lead-erythrocyte protoporphyrin correlation in blood of exposed workers. AU - Peter,F, AU - Reynolds,R G, PY - 1978/7/1/pubmed PY - 1978/7/1/medline PY - 1978/7/1/entrez SP - 144 EP - 9 JF - Health laboratory science JO - Health Lab Sci VL - 15 IS - 3 N2 - A systematic survey of blood samples from 174 industrial workers occupationally exposed to lead fumes and lead dust, revealed some poor correlations between the lead (Pb) level and the free erythrocyte protoporphyrin (FEP) level. In addition to those workers who had an expected correlation (normal Pb-normal FEP or elevated Pb-elevated FEP) there were two groups with atypical correlations. In one group a normal Pb level was associated with an elevated FEP level and in the other group an elevated Pb level was associated with a normal FEP level. This shows that neither the Pb nor the FEP test can substitute for the other. Since the individual FEP response to Pb absorption is unpredictable, both tests should be carried out routinely. This would make it possible to determine simultaneously the degree of absorption (Pb level) and the degree of intoxication (FEP level) and would improve significantly the assessment of undue lead absorption of occupationally exposed workers. If, however, only one of these tests is used for screening the other test should always be carried out as a confirmatory test when the screening detects an elevated Pb or FEP level. SN - 0017-9035 UR - https://www.unboundmedicine.com/medline/citation/701012/Lead_erythrocyte_protoporphyrin_correlation_in_blood_of_exposed_workers_ DB - PRIME DP - Unbound Medicine ER -