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[Use of an artificial B-cell in clinic and experimental medicine].
Z Gesamte Inn Med. 1981 Jan 01; 36(1):19-26.ZG

Abstract

Long-term hyperglycaemia in diabetics favours the development of diabetic microangiopathy. The clinical research, therefore, aims to find new opportunities to obtain normoglycaemia in insulin-dependent diabetics mainly by following three patts: -transplantation of pancreatic tissue or isolated islets of Langerhans - implantation of so-called hybrid pancreas and -construction of an artificial B-cell. This paper gives a review of the development, principle of function and clinical application of the glucose controlled insulin infusion system (closed loop system) and of the so-called open loop system without feedback to the glucose values. Results of our own investigations with GCIIS "Biostator", the development of an algorithm of our for the correlation between glucose and insulin behaviour and the first results with the insulin therapy with micropumps (open loop system) were demonstrated and discussed critically.

Authors

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Pub Type(s)

English Abstract
Journal Article

Language

ger

PubMed ID

7013292

Citation

Fischer, U, et al. "[Use of an Artificial B-cell in Clinic and Experimental Medicine]." Zeitschrift Fur Die Gesamte Innere Medizin Und Ihre Grenzgebiete, vol. 36, no. 1, 1981, pp. 19-26.
Fischer U, Bruns W, Jutzi E, et al. [Use of an artificial B-cell in clinic and experimental medicine]. Z Gesamte Inn Med. 1981;36(1):19-26.
Fischer, U., Bruns, W., Jutzi, E., Ratzmann, K. P., Abel, P., Bombor, H., Salzsieder, E., & Freyse, E. J. (1981). [Use of an artificial B-cell in clinic and experimental medicine]. Zeitschrift Fur Die Gesamte Innere Medizin Und Ihre Grenzgebiete, 36(1), 19-26.
Fischer U, et al. [Use of an Artificial B-cell in Clinic and Experimental Medicine]. Z Gesamte Inn Med. 1981 Jan 1;36(1):19-26. PubMed PMID: 7013292.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Use of an artificial B-cell in clinic and experimental medicine]. AU - Fischer,U, AU - Bruns,W, AU - Jutzi,E, AU - Ratzmann,K P, AU - Abel,P, AU - Bombor,H, AU - Salzsieder,E, AU - Freyse,E J, PY - 1981/1/1/pubmed PY - 1981/1/1/medline PY - 1981/1/1/entrez SP - 19 EP - 26 JF - Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete JO - Z Gesamte Inn Med VL - 36 IS - 1 N2 - Long-term hyperglycaemia in diabetics favours the development of diabetic microangiopathy. The clinical research, therefore, aims to find new opportunities to obtain normoglycaemia in insulin-dependent diabetics mainly by following three patts: -transplantation of pancreatic tissue or isolated islets of Langerhans - implantation of so-called hybrid pancreas and -construction of an artificial B-cell. This paper gives a review of the development, principle of function and clinical application of the glucose controlled insulin infusion system (closed loop system) and of the so-called open loop system without feedback to the glucose values. Results of our own investigations with GCIIS "Biostator", the development of an algorithm of our for the correlation between glucose and insulin behaviour and the first results with the insulin therapy with micropumps (open loop system) were demonstrated and discussed critically. SN - 0044-2542 UR - https://www.unboundmedicine.com/medline/citation/7013292/[Use_of_an_artificial_B_cell_in_clinic_and_experimental_medicine]_ L2 - https://medlineplus.gov/diabetesmedicines.html DB - PRIME DP - Unbound Medicine ER -