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Controlled clinical trial of five short-course (4-month) chemotherapy regimens in pulmonary tuberculosis. Second report of the 4th study. East African/British Medical Research Councils Study.
Am Rev Respir Dis 1981; 123(2):165-70AR

Abstract

We compared the bacteriologic relapse between 5 and 28 months for five 4-month chemotherapeutic regimens for pulmonary tuberculosis. The regimens were: (1) streptomycin plus isoniazid plus rifampin plus pyrazinamide daily for 8 wk followed by isoniazid plus rifampin plus pyrazinamide daily for 9 wk; (2) the same 4 initial drugs for 8 wk followed by isoniazid plus rifampin daily for 9 wk; (3) the same 4 initial drugs for 8 wk followed by isoniazid plus pyrazinamide daily for 9 wk; (4) the same 4 drugs for 8 wk followed by isoniazid daily for 9 wk; (5) the same as regimen 4; but without streptomycin for the first 8 wk. The first 2 regimens, in which rifampin was given for 4 months, had relapse rates of 16 and 11%, respectively, but the rates were much higher for the regimens in which rifampin was given for only 2 months (32 and 30 %, respectively). The addition of pyrazinamide in the continuation phase had no effect on relapse rate. Removal of the streptomycin (regimen 5) resulted in a relapse rate of 40%, but this was not significantly higher than that (30%) after regimen 4 (p = 0.2).

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

7015933

Citation

"Controlled Clinical Trial of Five Short-course (4-month) Chemotherapy Regimens in Pulmonary Tuberculosis. Second Report of the 4th Study. East African/British Medical Research Councils Study." The American Review of Respiratory Disease, vol. 123, no. 2, 1981, pp. 165-70.
Controlled clinical trial of five short-course (4-month) chemotherapy regimens in pulmonary tuberculosis. Second report of the 4th study. East African/British Medical Research Councils Study. Am Rev Respir Dis. 1981;123(2):165-70.
(1981). Controlled clinical trial of five short-course (4-month) chemotherapy regimens in pulmonary tuberculosis. Second report of the 4th study. East African/British Medical Research Councils Study. The American Review of Respiratory Disease, 123(2), pp. 165-70.
Controlled Clinical Trial of Five Short-course (4-month) Chemotherapy Regimens in Pulmonary Tuberculosis. Second Report of the 4th Study. East African/British Medical Research Councils Study. Am Rev Respir Dis. 1981;123(2):165-70. PubMed PMID: 7015933.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Controlled clinical trial of five short-course (4-month) chemotherapy regimens in pulmonary tuberculosis. Second report of the 4th study. East African/British Medical Research Councils Study. PY - 1981/2/1/pubmed PY - 1981/2/1/medline PY - 1981/2/1/entrez SP - 165 EP - 70 JF - The American review of respiratory disease JO - Am. Rev. Respir. Dis. VL - 123 IS - 2 N2 - We compared the bacteriologic relapse between 5 and 28 months for five 4-month chemotherapeutic regimens for pulmonary tuberculosis. The regimens were: (1) streptomycin plus isoniazid plus rifampin plus pyrazinamide daily for 8 wk followed by isoniazid plus rifampin plus pyrazinamide daily for 9 wk; (2) the same 4 initial drugs for 8 wk followed by isoniazid plus rifampin daily for 9 wk; (3) the same 4 initial drugs for 8 wk followed by isoniazid plus pyrazinamide daily for 9 wk; (4) the same 4 drugs for 8 wk followed by isoniazid daily for 9 wk; (5) the same as regimen 4; but without streptomycin for the first 8 wk. The first 2 regimens, in which rifampin was given for 4 months, had relapse rates of 16 and 11%, respectively, but the rates were much higher for the regimens in which rifampin was given for only 2 months (32 and 30 %, respectively). The addition of pyrazinamide in the continuation phase had no effect on relapse rate. Removal of the streptomycin (regimen 5) resulted in a relapse rate of 40%, but this was not significantly higher than that (30%) after regimen 4 (p = 0.2). SN - 0003-0805 UR - https://www.unboundmedicine.com/medline/citation/7015933/Controlled_clinical_trial_of_five_short_course__4_month__chemotherapy_regimens_in_pulmonary_tuberculosis__Second_report_of_the_4th_study__East_African/British_Medical_Research_Councils_Study_ L2 - http://www.atsjournals.org/doi/full/10.1164/arrd.1981.123.2.165?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -