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[Apthae: histologic, immunofluorescent and immuno--electron microscopy study of their pathogenesis].
Hautarzt. 1981 Jul; 32(7):364-9.H

Abstract

The present study was done to elucidate the pathogenesis of aphthae in recurrent oral ulcers and Behcet's disease. Histologically, early stages of aphthae showed a predominantly neutrophil infiltrate and leukocytoclasia in the vessel walls, as well as extravasates of erythrocytes. In later stages, also histiocytes and lymphocytes appeared. By direct immunofluorescence technique, 30 of 34 patients showed perivascular precipitates of C3 and Clq, eight patients in addition, IgM and IgG. Remarkably, band-like fine granular precipitates of C3 were present in the basement membrane zone. By immunoelectronmicroscopy, C3 was demonstrated in fine subendothelial granules of the vessel walls and of the epithelial basement membrane below the lamina densa. There were no fundamental differences between the aphthae of recurrent oral ulcers and Behcet's disease. Our findings indicate, that an immunecomplex vasculitis is involved in the pathogenesis of aphthosis.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

ger

PubMed ID

7021477

Citation

Luderschmidt, C, et al. "[Apthae: Histologic, Immunofluorescent and Immuno--electron Microscopy Study of Their Pathogenesis]." Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete, vol. 32, no. 7, 1981, pp. 364-9.
Luderschmidt C, Wolff HH, Scherer R. [Apthae: histologic, immunofluorescent and immuno--electron microscopy study of their pathogenesis]. Hautarzt. 1981;32(7):364-9.
Luderschmidt, C., Wolff, H. H., & Scherer, R. (1981). [Apthae: histologic, immunofluorescent and immuno--electron microscopy study of their pathogenesis]. Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete, 32(7), 364-9.
Luderschmidt C, Wolff HH, Scherer R. [Apthae: Histologic, Immunofluorescent and Immuno--electron Microscopy Study of Their Pathogenesis]. Hautarzt. 1981;32(7):364-9. PubMed PMID: 7021477.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Apthae: histologic, immunofluorescent and immuno--electron microscopy study of their pathogenesis]. AU - Luderschmidt,C, AU - Wolff,H H, AU - Scherer,R, PY - 1981/7/1/pubmed PY - 1981/7/1/medline PY - 1981/7/1/entrez SP - 364 EP - 9 JF - Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete JO - Hautarzt VL - 32 IS - 7 N2 - The present study was done to elucidate the pathogenesis of aphthae in recurrent oral ulcers and Behcet's disease. Histologically, early stages of aphthae showed a predominantly neutrophil infiltrate and leukocytoclasia in the vessel walls, as well as extravasates of erythrocytes. In later stages, also histiocytes and lymphocytes appeared. By direct immunofluorescence technique, 30 of 34 patients showed perivascular precipitates of C3 and Clq, eight patients in addition, IgM and IgG. Remarkably, band-like fine granular precipitates of C3 were present in the basement membrane zone. By immunoelectronmicroscopy, C3 was demonstrated in fine subendothelial granules of the vessel walls and of the epithelial basement membrane below the lamina densa. There were no fundamental differences between the aphthae of recurrent oral ulcers and Behcet's disease. Our findings indicate, that an immunecomplex vasculitis is involved in the pathogenesis of aphthosis. SN - 0017-8470 UR - https://www.unboundmedicine.com/medline/citation/7021477/[Apthae:_histologic_immunofluorescent_and_immuno__electron_microscopy_study_of_their_pathogenesis]_ L2 - https://medlineplus.gov/cankersores.html DB - PRIME DP - Unbound Medicine ER -