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[Mutagenicity of twelve imidazole derivatives with trichomonacide activity].
Boll Soc Ital Biol Sper 1981; 57(7):805-9BS

Abstract

The mutagenic action of twelve imidazole derivatives was investigated by Salmonella/microsome assay. All of them were mutagenic on TA 100 without metabolic activation. No direct relationship between antitrichomonad action in vitro and mutagenicity was established. As the compound XII showed much less mutagenic activity compared to the other imidazoles, we propose to perform more mutagenic studies on the chemical analogues of this drug.

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Pub Type(s)

English Abstract
Journal Article

Language

ita

PubMed ID

7023507

Citation

Belisario, M A., et al. "[Mutagenicity of Twelve Imidazole Derivatives With Trichomonacide Activity]." Bollettino Della Societa Italiana Di Biologia Sperimentale, vol. 57, no. 7, 1981, pp. 805-9.
Belisario MA, Quinto I, De Lorenzo F. [Mutagenicity of twelve imidazole derivatives with trichomonacide activity]. Boll Soc Ital Biol Sper. 1981;57(7):805-9.
Belisario, M. A., Quinto, I., & De Lorenzo, F. (1981). [Mutagenicity of twelve imidazole derivatives with trichomonacide activity]. Bollettino Della Societa Italiana Di Biologia Sperimentale, 57(7), pp. 805-9.
Belisario MA, Quinto I, De Lorenzo F. [Mutagenicity of Twelve Imidazole Derivatives With Trichomonacide Activity]. Boll Soc Ital Biol Sper. 1981 Apr 15;57(7):805-9. PubMed PMID: 7023507.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Mutagenicity of twelve imidazole derivatives with trichomonacide activity]. AU - Belisario,M A, AU - Quinto,I, AU - De Lorenzo,F, PY - 1981/4/15/pubmed PY - 1981/4/15/medline PY - 1981/4/15/entrez SP - 805 EP - 9 JF - Bollettino della Societa italiana di biologia sperimentale JO - Boll. Soc. Ital. Biol. Sper. VL - 57 IS - 7 N2 - The mutagenic action of twelve imidazole derivatives was investigated by Salmonella/microsome assay. All of them were mutagenic on TA 100 without metabolic activation. No direct relationship between antitrichomonad action in vitro and mutagenicity was established. As the compound XII showed much less mutagenic activity compared to the other imidazoles, we propose to perform more mutagenic studies on the chemical analogues of this drug. SN - 0037-8771 UR - https://www.unboundmedicine.com/medline/citation/7023507/[Mutagenicity_of_twelve_imidazole_derivatives_with_trichomonacide_activity] DB - PRIME DP - Unbound Medicine ER -