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Age-related association of insulin-dependent diabetes mellitus with BfF1 and the HLA-B18, BfF1 haplotype.
Diabetologia. 1981 Jul; 21(1):47-9.D

Abstract

Five hundred and ninety-nine patients with insulin-dependent (Type 1) diabetes mellitus were typed for Bf (factor B) polymorphism, and 318 of them for HLA-A, B and C antigens. Bf and HLA antigen frequencies were compared with those in 536 normal controls. A significant positive association between Type 1 diabetes and the rare factor B variant BfF1 was found (p less than 10(-3)), but this was present only in patients aged under 16 years at onset of the disease (p less than 0.005). There was a strongly positive linkage disequilibrium between BfF1 and HLA-B18 in the diabetic patients. This, too was especially pronounced in the juvenile onset cases, in whom it was significantly stronger than in controls (p less than 10(-3)). The known positive associations between Type 1 diabetes and HLA-B8, -B15 and -Cw3 were confirmed.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7024028

Citation

Bertrams, J, et al. "Age-related Association of Insulin-dependent Diabetes Mellitus With BfF1 and the HLA-B18, BfF1 Haplotype." Diabetologia, vol. 21, no. 1, 1981, pp. 47-9.
Bertrams J, Baur MP, Grüneklee D, et al. Age-related association of insulin-dependent diabetes mellitus with BfF1 and the HLA-B18, BfF1 haplotype. Diabetologia. 1981;21(1):47-9.
Bertrams, J., Baur, M. P., Grüneklee, D., & Gries, F. A. (1981). Age-related association of insulin-dependent diabetes mellitus with BfF1 and the HLA-B18, BfF1 haplotype. Diabetologia, 21(1), 47-9.
Bertrams J, et al. Age-related Association of Insulin-dependent Diabetes Mellitus With BfF1 and the HLA-B18, BfF1 Haplotype. Diabetologia. 1981;21(1):47-9. PubMed PMID: 7024028.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Age-related association of insulin-dependent diabetes mellitus with BfF1 and the HLA-B18, BfF1 haplotype. AU - Bertrams,J, AU - Baur,M P, AU - Grüneklee,D, AU - Gries,F A, PY - 1981/7/1/pubmed PY - 1981/7/1/medline PY - 1981/7/1/entrez SP - 47 EP - 9 JF - Diabetologia JO - Diabetologia VL - 21 IS - 1 N2 - Five hundred and ninety-nine patients with insulin-dependent (Type 1) diabetes mellitus were typed for Bf (factor B) polymorphism, and 318 of them for HLA-A, B and C antigens. Bf and HLA antigen frequencies were compared with those in 536 normal controls. A significant positive association between Type 1 diabetes and the rare factor B variant BfF1 was found (p less than 10(-3)), but this was present only in patients aged under 16 years at onset of the disease (p less than 0.005). There was a strongly positive linkage disequilibrium between BfF1 and HLA-B18 in the diabetic patients. This, too was especially pronounced in the juvenile onset cases, in whom it was significantly stronger than in controls (p less than 10(-3)). The known positive associations between Type 1 diabetes and HLA-B8, -B15 and -Cw3 were confirmed. SN - 0012-186X UR - https://www.unboundmedicine.com/medline/citation/7024028/Age_related_association_of_insulin_dependent_diabetes_mellitus_with_BfF1_and_the_HLA_B18_BfF1_haplotype_ L2 - http://www.diseaseinfosearch.org/result/2236 DB - PRIME DP - Unbound Medicine ER -