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Timing of insulin delivery with meals.
Horm Metab Res. 1981 Jul; 13(7):365-7.HM

Abstract

In non-diabetics neural and/or gastrointestinal humoral factors cause anticipatory insulin release with meals. The importance of this mechanism was illustrated by administration of a standard meal to six insulin dependent diabetics on two occasions. Insulin was delivered intravenously by an "open-loop" (preprogrammed) insulin infusion system designed to simulate the normal insulin response to meals. On one occasion insulin delivery was delayed 15 minutes. This time approximates the physiology delay before blood glucose rises after the start of a meal. The delay resulted in significantly greater hyperglycaemia continuing over three hours, compared with the study in which insulin delivery increased coincident with the start of the meal. A mechanism for initiating early insulin release with meals would be a helpful addition to "closed-loop" insulin delivery systems, this being apparent in a further comparison made between performance of the open-loop and closed-loop systems. Moreover, the delayed insulin response seen in maturity onset diabetics is likely to be an important cause of persistent hyperglycaemia.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7024077

Citation

Kraegen, E W., et al. "Timing of Insulin Delivery With Meals." Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, vol. 13, no. 7, 1981, pp. 365-7.
Kraegen EW, Chisholm DJ, McNamara ME. Timing of insulin delivery with meals. Horm Metab Res. 1981;13(7):365-7.
Kraegen, E. W., Chisholm, D. J., & McNamara, M. E. (1981). Timing of insulin delivery with meals. Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, 13(7), 365-7.
Kraegen EW, Chisholm DJ, McNamara ME. Timing of Insulin Delivery With Meals. Horm Metab Res. 1981;13(7):365-7. PubMed PMID: 7024077.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Timing of insulin delivery with meals. AU - Kraegen,E W, AU - Chisholm,D J, AU - McNamara,M E, PY - 1981/7/1/pubmed PY - 1981/7/1/medline PY - 1981/7/1/entrez SP - 365 EP - 7 JF - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme JO - Horm Metab Res VL - 13 IS - 7 N2 - In non-diabetics neural and/or gastrointestinal humoral factors cause anticipatory insulin release with meals. The importance of this mechanism was illustrated by administration of a standard meal to six insulin dependent diabetics on two occasions. Insulin was delivered intravenously by an "open-loop" (preprogrammed) insulin infusion system designed to simulate the normal insulin response to meals. On one occasion insulin delivery was delayed 15 minutes. This time approximates the physiology delay before blood glucose rises after the start of a meal. The delay resulted in significantly greater hyperglycaemia continuing over three hours, compared with the study in which insulin delivery increased coincident with the start of the meal. A mechanism for initiating early insulin release with meals would be a helpful addition to "closed-loop" insulin delivery systems, this being apparent in a further comparison made between performance of the open-loop and closed-loop systems. Moreover, the delayed insulin response seen in maturity onset diabetics is likely to be an important cause of persistent hyperglycaemia. SN - 0018-5043 UR - https://www.unboundmedicine.com/medline/citation/7024077/Timing_of_insulin_delivery_with_meals_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2007-1019271 DB - PRIME DP - Unbound Medicine ER -