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Fetal and material ovine placental lactogen during hyperglycaemia, hypoglycaemia and fasting.

Abstract

Hyperglycaemia was produced in chronically catheterized fetal lambs and pregnant-ewes by the infusion of glucose into the fetus. Plasma concentration of placenta lactogen did not change significantly in either fetal or maternal circulation. Fetal and maternal hypoglycaemia was induced by administration of insulin to the fetus and ewe separately. Plasma concentrations of placental lactogen in the fetus did not change significantly but maternal plasma concentrations fell slightly after hypoglycaemia in either fetus or ewe. Plasma concentrations of placental lactogen rose in both the ewe and fetus during prolonged fasting of the ewe. These results neither confirm nor refute a role for placental lactogen in intermediary metabolism of the pregnant ewe and fetus but glucose concentration alone is unlikely to be a significant factor in the control of secretion of this hormone.

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  • Publisher Full Text
  • Authors

    , , ,

    Source

    The Journal of endocrinology 90:3 1981 Sep pg 337-43

    MeSH

    Animals
    Blood Glucose
    Fasting
    Female
    Fetal Blood
    Glucose
    Hyperglycemia
    Hypoglycemia
    Insulin
    Maternal-Fetal Exchange
    Placental Lactogen
    Pregnancy
    Sheep

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    7024455

    Citation

    Brinsmead, M W., et al. "Fetal and Material Ovine Placental Lactogen During Hyperglycaemia, Hypoglycaemia and Fasting." The Journal of Endocrinology, vol. 90, no. 3, 1981, pp. 337-43.
    Brinsmead MW, Bancroft BJ, Thorburn GD, et al. Fetal and material ovine placental lactogen during hyperglycaemia, hypoglycaemia and fasting. J Endocrinol. 1981;90(3):337-43.
    Brinsmead, M. W., Bancroft, B. J., Thorburn, G. D., & Waters, M. J. (1981). Fetal and material ovine placental lactogen during hyperglycaemia, hypoglycaemia and fasting. The Journal of Endocrinology, 90(3), pp. 337-43.
    Brinsmead MW, et al. Fetal and Material Ovine Placental Lactogen During Hyperglycaemia, Hypoglycaemia and Fasting. J Endocrinol. 1981;90(3):337-43. PubMed PMID: 7024455.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Fetal and material ovine placental lactogen during hyperglycaemia, hypoglycaemia and fasting. AU - Brinsmead,M W, AU - Bancroft,B J, AU - Thorburn,G D, AU - Waters,M J, PY - 1981/9/1/pubmed PY - 1981/9/1/medline PY - 1981/9/1/entrez SP - 337 EP - 43 JF - The Journal of endocrinology JO - J. Endocrinol. VL - 90 IS - 3 N2 - Hyperglycaemia was produced in chronically catheterized fetal lambs and pregnant-ewes by the infusion of glucose into the fetus. Plasma concentration of placenta lactogen did not change significantly in either fetal or maternal circulation. Fetal and maternal hypoglycaemia was induced by administration of insulin to the fetus and ewe separately. Plasma concentrations of placental lactogen in the fetus did not change significantly but maternal plasma concentrations fell slightly after hypoglycaemia in either fetus or ewe. Plasma concentrations of placental lactogen rose in both the ewe and fetus during prolonged fasting of the ewe. These results neither confirm nor refute a role for placental lactogen in intermediary metabolism of the pregnant ewe and fetus but glucose concentration alone is unlikely to be a significant factor in the control of secretion of this hormone. SN - 0022-0795 UR - https://www.unboundmedicine.com/medline/citation/7024455/Fetal_and_material_ovine_placental_lactogen_during_hyperglycaemia_hypoglycaemia_and_fasting_ L2 - https://joe.bioscientifica.com/doi/10.1677/joe.0.0900337 DB - PRIME DP - Unbound Medicine ER -