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Hycanthone therapy in selected patients with S. mansoni and S. haematobium infections in the Sudan.
J Trop Med Hyg. 1978 Jul; 81(7):126-30.JT

Abstract

The results of a clinical trial of hycanthone in 601 selected Sudanese patients with S. mansoni and S. haematobium infections are reported. Hycanthone was given as a single intramuscular injection at a dose of 3.0 mg per kilogramme body weight. The commonest side effects were nausea and vomiting which occurred in 35 per cent and 32 per cent respectively. No incidence of acute hepatic damage and no deaths were encountered. About one third of patients reported for follow-up. Cure rate for S. mansoni was 90 per cent at 6 weeks of treatment and 97 per cent at three months and six months, while for S. haematobium infection it was 82 per cent at 6 weeks and 91 per cent at 3 months and 6 months. A significant reduction in egg excretion was achieved in those who were not cured.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

702619

Citation

Salih, S Y., et al. "Hycanthone Therapy in Selected Patients With S. Mansoni and S. Haematobium Infections in the Sudan." The Journal of Tropical Medicine and Hygiene, vol. 81, no. 7, 1978, pp. 126-30.
Salih SY, Abu Sabaa H, Mustafa D. Hycanthone therapy in selected patients with S. mansoni and S. haematobium infections in the Sudan. J Trop Med Hyg. 1978;81(7):126-30.
Salih, S. Y., Abu Sabaa, H., & Mustafa, D. (1978). Hycanthone therapy in selected patients with S. mansoni and S. haematobium infections in the Sudan. The Journal of Tropical Medicine and Hygiene, 81(7), 126-30.
Salih SY, Abu Sabaa H, Mustafa D. Hycanthone Therapy in Selected Patients With S. Mansoni and S. Haematobium Infections in the Sudan. J Trop Med Hyg. 1978;81(7):126-30. PubMed PMID: 702619.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hycanthone therapy in selected patients with S. mansoni and S. haematobium infections in the Sudan. AU - Salih,S Y, AU - Abu Sabaa,H, AU - Mustafa,D, PY - 1978/7/1/pubmed PY - 1978/7/1/medline PY - 1978/7/1/entrez SP - 126 EP - 30 JF - The Journal of tropical medicine and hygiene JO - J Trop Med Hyg VL - 81 IS - 7 N2 - The results of a clinical trial of hycanthone in 601 selected Sudanese patients with S. mansoni and S. haematobium infections are reported. Hycanthone was given as a single intramuscular injection at a dose of 3.0 mg per kilogramme body weight. The commonest side effects were nausea and vomiting which occurred in 35 per cent and 32 per cent respectively. No incidence of acute hepatic damage and no deaths were encountered. About one third of patients reported for follow-up. Cure rate for S. mansoni was 90 per cent at 6 weeks of treatment and 97 per cent at three months and six months, while for S. haematobium infection it was 82 per cent at 6 weeks and 91 per cent at 3 months and 6 months. A significant reduction in egg excretion was achieved in those who were not cured. SN - 0022-5304 UR - https://www.unboundmedicine.com/medline/citation/702619/Hycanthone_therapy_in_selected_patients_with_S__mansoni_and_S__haematobium_infections_in_the_Sudan_ DB - PRIME DP - Unbound Medicine ER -